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R-spondin Is More Than Just Wnt's Sidekick.
Huels, David J; Sansom, Owen J.
Affiliation
  • Huels DJ; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands; Cancer Genomics Netherlands, Academic Medical Center, the Netherlands.
  • Sansom OJ; Cancer Research UK Beatson Institute, Glasgow, Scotland; Institute of Cancer Sciences, University Of Glasgow, Glasgow, Scotland. Electronic address: o.sansom@beatson.gla.ac.uk.
Dev Cell ; 41(5): 456-458, 2017 06 05.
Article in En | MEDLINE | ID: mdl-28586642
ABSTRACT
The intestinal crypt and its stem cells are dependent on the Wnt pathway. Reporting in Nature, Yan et al. (2017) show that Wnts and Wnt signaling potentiator R-spondins have non-interchangeable roles. Both are necessary for intestinal stem cell (ISC) maintenance, and R-spondins are the limiting factor that defines ISC number.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombospondins / Wnt Signaling Pathway Limits: Humans Language: En Journal: Dev Cell Journal subject: EMBRIOLOGIA Year: 2017 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombospondins / Wnt Signaling Pathway Limits: Humans Language: En Journal: Dev Cell Journal subject: EMBRIOLOGIA Year: 2017 Document type: Article Affiliation country: