Enhancement of the antiproliferative activity of [RuCp(PPh3)2(dmoPTA-1κP)]+via its coordination to one {CoCl2} unit: synthesis, crystal structure and properties of [RuCp(PPh3)2-µ-dmoPTA-1κP:2κ2N,N'-CoCl2](OTf)·0.25H2O.

ABSTRACT

Synthesis, characterization and the antiproliferative activity of a new bimetallic complex [RuCp(PPh3)2-µ-dmoPTA-1κP2k2N,N'-CoCl2]OTf·0.25H2O are described. The stability of the complex was studied under air and N2 atmospheres and in CDCl3, DMSO, water and the cell culture medium, at room temperature and 40 °C. The complex showed an enhanced antiproliferative activity (up to six-fold) when compared with its parent complex [RuCp(PPh3)2(HdmoPTA)]2+ against human lung, cervix, breast, and colon solid tumor cell lines.