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Topical Fibronectin Improves Wound Healing of Irradiated Skin.
Johnson, Maxwell B; Pang, Brandon; Gardner, Daniel J; Niknam-Benia, Solmaz; Soundarajan, Vinaya; Bramos, Athanasios; Perrault, David P; Banks, Kian; Lee, Gene K; Baker, Regina Y; Kim, Gene H; Lee, Sunju; Chai, Yang; Chen, Mei; Li, Wei; Kwong, Lawrence; Hong, Young-Kwon; Wong, Alex K.
Affiliation
  • Johnson MB; Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, 1510 San Pablo St., Suite 415, Los Angeles, CA, 90033, USA.
  • Pang B; Department of Surgery, Keck School of Medicine of USC, 1510 San Pablo St., Suite 415, Los Angeles, CA, 90033, USA.
  • Gardner DJ; Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, 1510 San Pablo St., Suite 415, Los Angeles, CA, 90033, USA.
  • Niknam-Benia S; Department of Surgery, Keck School of Medicine of USC, 1510 San Pablo St., Suite 415, Los Angeles, CA, 90033, USA.
  • Soundarajan V; Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, 1510 San Pablo St., Suite 415, Los Angeles, CA, 90033, USA.
  • Bramos A; Department of Surgery, Keck School of Medicine of USC, 1510 San Pablo St., Suite 415, Los Angeles, CA, 90033, USA.
  • Perrault DP; Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, 1510 San Pablo St., Suite 415, Los Angeles, CA, 90033, USA.
  • Banks K; Department of Surgery, Keck School of Medicine of USC, 1510 San Pablo St., Suite 415, Los Angeles, CA, 90033, USA.
  • Lee GK; Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, 1510 San Pablo St., Suite 415, Los Angeles, CA, 90033, USA.
  • Baker RY; Department of Surgery, Keck School of Medicine of USC, 1510 San Pablo St., Suite 415, Los Angeles, CA, 90033, USA.
  • Kim GH; Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, 1510 San Pablo St., Suite 415, Los Angeles, CA, 90033, USA.
  • Lee S; Department of Surgery, Keck School of Medicine of USC, 1510 San Pablo St., Suite 415, Los Angeles, CA, 90033, USA.
  • Chai Y; Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, 1510 San Pablo St., Suite 415, Los Angeles, CA, 90033, USA.
  • Chen M; Department of Surgery, Keck School of Medicine of USC, 1510 San Pablo St., Suite 415, Los Angeles, CA, 90033, USA.
  • Li W; Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, 1510 San Pablo St., Suite 415, Los Angeles, CA, 90033, USA.
  • Kwong L; Department of Surgery, Keck School of Medicine of USC, 1510 San Pablo St., Suite 415, Los Angeles, CA, 90033, USA.
  • Hong YK; Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, 1510 San Pablo St., Suite 415, Los Angeles, CA, 90033, USA.
  • Wong AK; Department of Surgery, Keck School of Medicine of USC, 1510 San Pablo St., Suite 415, Los Angeles, CA, 90033, USA.
Sci Rep ; 7(1): 3876, 2017 06 20.
Article in En | MEDLINE | ID: mdl-28634413
ABSTRACT
Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, fibronectin was the most significantly and consistently downregulated in radiation-damaged skin. Using a murine model, we confirmed that radiation leads to decreased fibronectin expression in the skin as well as delayed wound healing. Topically applied fibronectin was found to significantly improve wound healing in irradiated skin and was associated with decreased inflammatory infiltrate and increased angiogenesis. Fibronectin treatment may be a useful adjunctive modality in the treatment of non-healing radiation wounds.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radiation Injuries / Skin / Wound Healing / Fibronectins Limits: Animals / Humans / Male Language: En Journal: Sci Rep Year: 2017 Document type: Article Affiliation country:
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radiation Injuries / Skin / Wound Healing / Fibronectins Limits: Animals / Humans / Male Language: En Journal: Sci Rep Year: 2017 Document type: Article Affiliation country: