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Supramolecular surface functionalization via catechols for the improvement of cell-material interactions.
Spaans, S; Fransen, P P K H; Ippel, B D; de Bont, D F A; Keizer, H M; Bax, N A M; Bouten, C V C; Dankers, P Y W.
Affiliation
  • Spaans S; Institute for Complex Molecular Systems, Eindhoven University of Technology, De Zaale, 5612 AJ Eindhoven, The Netherlands. p.y.w.dankers@tue.nl and Department of Biomedical Engineering, Soft Tissue Engineering and Mechanobiology, Eindhoven University of Technology, P.O box 513, 5600 MB Eindhoven, Th
  • Fransen PPKH; Institute for Complex Molecular Systems, Eindhoven University of Technology, De Zaale, 5612 AJ Eindhoven, The Netherlands. p.y.w.dankers@tue.nl and Department of Biomedical Engineering, Laboratory of Chemical Biology, Eindhoven University of Technology, P.O. box 513, 5600 MB Eindhoven, The Netherlan
  • Ippel BD; Institute for Complex Molecular Systems, Eindhoven University of Technology, De Zaale, 5612 AJ Eindhoven, The Netherlands. p.y.w.dankers@tue.nl and Department of Biomedical Engineering, Soft Tissue Engineering and Mechanobiology, Eindhoven University of Technology, P.O box 513, 5600 MB Eindhoven, Th
  • de Bont DFA; Institute for Complex Molecular Systems, Eindhoven University of Technology, De Zaale, 5612 AJ Eindhoven, The Netherlands. p.y.w.dankers@tue.nl and Department of Biomedical Engineering, Soft Tissue Engineering and Mechanobiology, Eindhoven University of Technology, P.O box 513, 5600 MB Eindhoven, Th
  • Keizer HM; SyMO-Chem BV, Eindhoven University of Technology, De Zaale, 5612 AZ Eindhoven, The Netherlands.
  • Bax NAM; Institute for Complex Molecular Systems, Eindhoven University of Technology, De Zaale, 5612 AJ Eindhoven, The Netherlands. p.y.w.dankers@tue.nl and Department of Biomedical Engineering, Soft Tissue Engineering and Mechanobiology, Eindhoven University of Technology, P.O box 513, 5600 MB Eindhoven, Th
  • Bouten CVC; Institute for Complex Molecular Systems, Eindhoven University of Technology, De Zaale, 5612 AJ Eindhoven, The Netherlands. p.y.w.dankers@tue.nl and Department of Biomedical Engineering, Soft Tissue Engineering and Mechanobiology, Eindhoven University of Technology, P.O box 513, 5600 MB Eindhoven, Th
  • Dankers PYW; Institute for Complex Molecular Systems, Eindhoven University of Technology, De Zaale, 5612 AJ Eindhoven, The Netherlands. p.y.w.dankers@tue.nl and Department of Biomedical Engineering, Soft Tissue Engineering and Mechanobiology, Eindhoven University of Technology, P.O box 513, 5600 MB Eindhoven, Th
Biomater Sci ; 5(8): 1541-1548, 2017 Jul 25.
Article in En | MEDLINE | ID: mdl-28636048
ABSTRACT
Optimization of cell-material interactions is crucial for the success of synthetic biomaterials in guiding tissue regeneration. To do so, catechol chemistry is often used to introduce adhesiveness into biomaterials. Here, a supramolecular approach based on ureido-pyrimidinone (UPy) modified polymers is combined with catechol chemistry in order to achieve improved cellular adhesion onto supramolecular biomaterials. UPy-modified hydrophobic polymers with non-cell adhesive properties are developed that can be bioactivated via a modular approach using UPy-modified catechols. It is shown that successful formulation of the UPy-catechol additive with the UPy-polymer results in surfaces that induce cardiomyocyte progenitor cell adhesion, cell spreading, and preservation of cardiac specific extracellular matrix production. Hence, by functionalizing supramolecular surfaces with catechol functionalities, an adhesive supramolecular biomaterial is developed that allows for the possibility to contribute to biomaterial-based regeneration.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biocompatible Materials / Catechols Language: En Journal: Biomater Sci Year: 2017 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biocompatible Materials / Catechols Language: En Journal: Biomater Sci Year: 2017 Document type: Article Affiliation country: