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The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue.
Schugar, Rebecca C; Shih, Diana M; Warrier, Manya; Helsley, Robert N; Burrows, Amy; Ferguson, Daniel; Brown, Amanda L; Gromovsky, Anthony D; Heine, Markus; Chatterjee, Arunachal; Li, Lin; Li, Xinmin S; Wang, Zeneng; Willard, Belinda; Meng, YongHong; Kim, Hanjun; Che, Nam; Pan, Calvin; Lee, Richard G; Crooke, Rosanne M; Graham, Mark J; Morton, Richard E; Langefeld, Carl D; Das, Swapan K; Rudel, Lawrence L; Zein, Nizar; McCullough, Arthur J; Dasarathy, Srinivasan; Tang, W H Wilson; Erokwu, Bernadette O; Flask, Chris A; Laakso, Markku; Civelek, Mete; Naga Prasad, Sathyamangla V; Heeren, Joerg; Lusis, Aldons J; Hazen, Stanley L; Brown, J Mark.
Affiliation
  • Schugar RC; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Shih DM; Departments of Medicine, Microbiology, and Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Warrier M; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Helsley RN; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Burrows A; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Ferguson D; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Brown AL; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Gromovsky AD; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Heine M; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
  • Chatterjee A; Department of Molecular Cardiology, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Li L; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Li XS; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Wang Z; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Willard B; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Meng Y; Departments of Medicine, Microbiology, and Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Kim H; Departments of Medicine, Microbiology, and Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Che N; Departments of Medicine, Microbiology, and Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Pan C; Departments of Medicine, Microbiology, and Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Lee RG; Cardiovascular Group, Antisense Drug Discovery, Ionis Pharmaceuticals, Inc., Carlsbad, CA 92010, USA.
  • Crooke RM; Cardiovascular Group, Antisense Drug Discovery, Ionis Pharmaceuticals, Inc., Carlsbad, CA 92010, USA.
  • Graham MJ; Cardiovascular Group, Antisense Drug Discovery, Ionis Pharmaceuticals, Inc., Carlsbad, CA 92010, USA.
  • Morton RE; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Langefeld CD; Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1040, USA.
  • Das SK; Department of Endocrinology and Metabolism, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1040, USA.
  • Rudel LL; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1040, USA.
  • Zein N; Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA.
  • McCullough AJ; Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Dasarathy S; Department of Pathobiology, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Tang WHW; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Erokwu BO; Departments of Radiology, Biomedical Engineering, and Pediatrics, Case Western Reserve University, Cleveland, OH 44195, USA.
  • Flask CA; Departments of Radiology, Biomedical Engineering, and Pediatrics, Case Western Reserve University, Cleveland, OH 44195, USA.
  • Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
  • Civelek M; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22904, USA.
  • Naga Prasad SV; Department of Molecular Cardiology, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Heeren J; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
  • Lusis AJ; Departments of Medicine, Microbiology, and Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Hazen SL; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Brown JM; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, OH 44195, USA. Electronic address: brownm5@ccf.org.
Cell Rep ; 19(12): 2451-2461, 2017 06 20.
Article in En | MEDLINE | ID: mdl-28636934

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxygenases / Subcutaneous Fat / Methylamines / Obesity Limits: Animals / Female / Humans / Male Language: En Journal: Cell Rep Year: 2017 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxygenases / Subcutaneous Fat / Methylamines / Obesity Limits: Animals / Female / Humans / Male Language: En Journal: Cell Rep Year: 2017 Document type: Article Affiliation country: Country of publication: