Histamine release positive test associates with disease remission in chronic spontaneous urticaria: a proof-of-concept study.
Eur Ann Allergy Clin Immunol
; 49(4): 154-160, 2017 Jul.
Article
in En
| MEDLINE
| ID: mdl-28752718
ABSTRACT
SUMMARY:
Background. Histamine release (HR) test has previously been shown to predict the presence of endogenous histamine-releasing factors in chronic spontaneous urticaria (CSU). Objectives and methods. Twenty CSU patients unresponsive to antihistamine treatment were enrolled in order to evaluate the correlations between HR test results and demographic features, quality of life, disease activity, clinical course, and autologous serum and plasma skin tests (ASST and APST). Results. All patients with positive HR test (9/9, 100%) had a more severe disease activity at onset (urticaria activity score, UAS > 2) when compared to negative HR test patients (5/11; p = 0.04). Quality of life questionnaire's results were not substantially different between HR positive and negative subgroups at baseline (p > 0.05), and results of HR test and ASST/APST did not co-segregate (p > 0.05). After 12 months, patients with a positive HR test had a significant reduction of disease activity (p = 0.003) whereas patients with a negative HR test did not (p > 0.05), leading to disease remission and antihistamine treatment withdrawal in 67% (6/9) of positive HR test patients versus 18% (2/11) of negative HR test patients (p = 0.027). Conclusions. Positive HR test may predict spontaneous CSU remission at 12 months.Key words
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Urticaria
/
Immunologic Tests
/
Histamine Antagonists
/
Histamine Release
/
Mast Cells
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Aspects:
Patient_preference
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Eur Ann Allergy Clin Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2017
Document type:
Article