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Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models.
Yamada, Ken; Levell, Julian; Yoon, Taeyong; Kohls, Darcy; Yowe, David; Rigel, Dean F; Imase, Hidetomo; Yuan, Jun; Yasoshima, Kayo; DiPetrillo, Keith; Monovich, Lauren; Xu, Lingfei; Zhu, Meicheng; Kato, Mitsunori; Jain, Monish; Idamakanti, Neeraja; Taslimi, Paul; Kawanami, Toshio; Argikar, Upendra A; Kunjathoor, Vidya; Xie, Xiaoling; Yagi, Yukiko I; Iwaki, Yuki; Robinson, Zachary; Park, Hyi-Man.
Affiliation
  • Yamada K; Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
  • Levell J; Novartis Institutes for BioMedical Research, Novartis Pharma K.K. , Tsukuba, Ibaraki 300-2611, Japan.
  • Yoon T; Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
  • Kohls D; Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
  • Yowe D; Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
  • Rigel DF; Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
  • Imase H; Novartis Institutes for BioMedical Research, Novartis Pharmaceuticals Corporation , East Hanover, New Jersey 07936-1080, United States.
  • Yuan J; Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
  • Yasoshima K; Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
  • DiPetrillo K; Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
  • Monovich L; Novartis Institutes for BioMedical Research, Novartis Pharma K.K. , Tsukuba, Ibaraki 300-2611, Japan.
  • Xu L; Novartis Institutes for BioMedical Research, Novartis Pharmaceuticals Corporation , East Hanover, New Jersey 07936-1080, United States.
  • Zhu M; Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
  • Kato M; Novartis Institutes for BioMedical Research, Novartis Pharmaceuticals Corporation , East Hanover, New Jersey 07936-1080, United States.
  • Jain M; Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
  • Idamakanti N; Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
  • Taslimi P; Novartis Institutes for BioMedical Research, Novartis Pharma K.K. , Tsukuba, Ibaraki 300-2611, Japan.
  • Kawanami T; Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
  • Argikar UA; Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
  • Kunjathoor V; Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
  • Xie X; Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
  • Yagi YI; Novartis Institutes for BioMedical Research, Novartis Pharma K.K. , Tsukuba, Ibaraki 300-2611, Japan.
  • Iwaki Y; Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
  • Robinson Z; Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
  • Park HM; Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
J Med Chem ; 60(16): 7099-7107, 2017 08 24.
Article in En | MEDLINE | ID: mdl-28771350
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Thiazoles / Protein Serine-Threonine Kinases / Intracellular Signaling Peptides and Proteins / Protein Kinase Inhibitors / Hypertension / Antihypertensive Agents Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2017 Document type: Article Affiliation country:
Fulltext
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Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Thiazoles / Protein Serine-Threonine Kinases / Intracellular Signaling Peptides and Proteins / Protein Kinase Inhibitors / Hypertension / Antihypertensive Agents Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2017 Document type: Article Affiliation country: