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Short-term side effects and attitudes towards second donation: A comparison of related and unrelated haematopoietic stem cell donors.
Pahnke, Simon; Larfors, Gunnar; Axdorph-Nygell, Ulla; Fischer-Nielsen, Anne; Haastrup, Eva; Heldal, Dag; Itälä-Remes, Maija; Johansson, Jan-Erik; Kauppila, Marjut; Lenhoff, Stig; Ljungman, Per; Niittyvuopio, Riita; Sandstedt, Anna; Hägglund, Hans.
Affiliation
  • Pahnke S; Department of Haematology, Uppsala University Hospital, Uppsala, Sweden.
  • Larfors G; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
  • Axdorph-Nygell U; Department of Haematology, Uppsala University Hospital, Uppsala, Sweden.
  • Fischer-Nielsen A; Centre for Apheresis and Stem Cell Processing (CASH), Clinical Immunology/Transfusion Medicine, and Department of Haematology, Karolinska University Hospital, Stockholm, Sweden.
  • Haastrup E; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
  • Heldal D; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
  • Itälä-Remes M; Department of Haematology, Oslo University Hospital, Oslo, Norway.
  • Johansson JE; Stem Cell Transplantation Unit, Turku University Hospital, Turku, Finland.
  • Kauppila M; Department of Haematology and Coagulation, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Lenhoff S; Department of Haematology, Turku University Hospital, Turku, Finland.
  • Ljungman P; Department of Haematology, Skåne University Hospital, Lund, Sweden.
  • Niittyvuopio R; Department of Haematology, Karolinska University Hospital, Division of Haematology, Karolinska Institutet, Stockholm, Sweden.
  • Sandstedt A; Department of Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Division of Haematology, Karolinska Institutet, Stockholm, Sweden.
  • Hägglund H; Department of Medicine Huddinge, Karolinska University Hospital, Division of Haematology, Karolinska Institutet, Stockholm, Sweden.
J Clin Apher ; 33(3): 226-235, 2018 Jun.
Article in En | MEDLINE | ID: mdl-28833474
ABSTRACT
The Nordic Register of Haematopoietic Stem Cell Donors (NRHSD) has registered related and unrelated donors from 10 transplant centres in Sweden, Norway, Finland and Denmark since 1998. We present a prospective, observational study of 1,957 donors, focusing mainly on the differences between related and unrelated donors. Related donors are reported to have more comorbidities, but similar side effects compared with unrelated donors. Side effects after BM or PBSC donation are generally of short duration and in this study no deaths, myocardial infarctions, splenic ruptures, or thromboembolic events are reported. Interestingly, related donors express more hesitancy towards donating again when asked 1 month after donation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tissue Donors / Unrelated Donors Type of study: Clinical_trials / Observational_studies Limits: Humans Country/Region as subject: Europa Language: En Journal: J Clin Apher Year: 2018 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tissue Donors / Unrelated Donors Type of study: Clinical_trials / Observational_studies Limits: Humans Country/Region as subject: Europa Language: En Journal: J Clin Apher Year: 2018 Document type: Article Affiliation country: