The metabolic changes in tumor-associated macrophages during cancer grow in mice with Ehrlich ascites carcinoma.
Dokl Biochem Biophys
; 475(1): 277-279, 2017 Jul.
Article
in En
| MEDLINE
| ID: mdl-28864893
ABSTRACT
In this work, we investigated the activity of the key NAD(P)-dependent dehydrogenases associated with macrophage tumors in mice with Ehrlich ascites carcinoma. It was shown that cancer grow is associated with the development of conditions in macrophages leading to a decrease in the substrate flow intensity in the tricarboxylic acid cycle, deceleration of oxidative deamination of L-glutamate, NADP regeneration, and a decrease in the antioxidant defense efficiency. There results are consistent with our recent concept on the nonspecific metabolic reaction of cells to extreme exposures.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Ehrlich Tumor
/
Macrophages
Type of study:
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
Dokl Biochem Biophys
Journal subject:
BIOFISICA
/
BIOQUIMICA
Year:
2017
Document type:
Article
Affiliation country: