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Maximal number of pre-synaptic ribbons are formed in cochlear region corresponding to middle frequency in mice.
Yang, Le; Chen, DaiShi; Qu, TengFei; Ding, TongHui; Yan, AiHui; Gong, Pinggui; Liu, Yunyi; Zhang, Junjun; Gong, ShuSheng; Yang, ShiMing; Peng, Hong; Liu, Ke.
Affiliation
  • Yang L; a Department of Otolaryngology-Head and Neck Surgery , Guangdong Second Provincial General Hospital, Southern Medical University , Guangzhou , People's Republic of China.
  • Chen D; b Department of Otolaryngology-Head and Neck Surgery , Chinese PLA General Hospital , Beijing , People's Republic of China.
  • Qu T; c Department of Otolaryngology-Head and Neck Surgery , Beijing Friendship Hospital, Capital Medical University , Beijing , People's Republic of China.
  • Ding T; d Department of Otolaryngology-Head and Neck Surgery , The First Affiliated Hospital of China Medical University , Shenyang , People's Republic of China.
  • Yan A; d Department of Otolaryngology-Head and Neck Surgery , The First Affiliated Hospital of China Medical University , Shenyang , People's Republic of China.
  • Gong P; a Department of Otolaryngology-Head and Neck Surgery , Guangdong Second Provincial General Hospital, Southern Medical University , Guangzhou , People's Republic of China.
  • Liu Y; a Department of Otolaryngology-Head and Neck Surgery , Guangdong Second Provincial General Hospital, Southern Medical University , Guangzhou , People's Republic of China.
  • Zhang J; a Department of Otolaryngology-Head and Neck Surgery , Guangdong Second Provincial General Hospital, Southern Medical University , Guangzhou , People's Republic of China.
  • Gong S; c Department of Otolaryngology-Head and Neck Surgery , Beijing Friendship Hospital, Capital Medical University , Beijing , People's Republic of China.
  • Yang S; b Department of Otolaryngology-Head and Neck Surgery , Chinese PLA General Hospital , Beijing , People's Republic of China.
  • Peng H; e Department of Otolaryngology-Head and Neck Surgery , Guangdong Second Provincial General Hospital , Guangzhou , People's Republic of China.
  • Liu K; c Department of Otolaryngology-Head and Neck Surgery , Beijing Friendship Hospital, Capital Medical University , Beijing , People's Republic of China.
Acta Otolaryngol ; 138(1): 25-30, 2018 Jan.
Article in En | MEDLINE | ID: mdl-28949268
ABSTRACT

OBJECTIVE:

To investigate whether there are more quantitative pre-synaptic ribbons formed in the cochlear region corresponding to middle-frequency in cochlea of mice.

METHODS:

Counts of pre-synaptic ribbons were performed using immunostaining and laser confocal microscopy. Hearing thresholds and function of ribbon synapses were estimated by auditory brain response (ABR) and compound action potential (CAP). Cochlear mapping has been achieved to match the frequencies and corresponding regions along the cochlear spiral.

RESULTS:

The number of pre-synaptic ribbons in per inner hair cell (IHC) has been found to increase gradually from the base turn, the maximal quantity appeared at the region of 50-70% from the apex. Next, ABR thresholds showed that there was the lowest ABR threshold in the frequency around 8-16 kHz, corresponding to the region of 50-70% from the apex according to the cochlear mapping. Further, CAP amplitudes were estimated, and the maximal value identified at the same frequency (8-16 kHz).

CONCLUSIONS:

Maximal number of pre-synaptic ribbons is formed in the cochlear region of middle frequency in mice, coupling with the lowest ABR threshold and highest CAP amplitudes. Our study shows that the middle frequency (8-16 kHz) could be the most sensitive region to sound stimuli in mice.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Cochlea / Hair Cells, Auditory, Inner Limits: Animals Language: En Journal: Acta Otolaryngol Year: 2018 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Cochlea / Hair Cells, Auditory, Inner Limits: Animals Language: En Journal: Acta Otolaryngol Year: 2018 Document type: Article