A unique case of nephrogenic systemic fibrosis from gadolinium exposure in a patient with normal eGFR.
BMJ Case Rep
; 20172017 Oct 11.
Article
in En
| MEDLINE
| ID: mdl-29025775
ABSTRACT
A 57-year-old woman presented with swelling and thickening of the skin of the lower extremities. Three months prior to presentation, patient had MRI with gadolinium as part of an evaluation for suspected pancreatic malignancy. Creatinine levels at the time of gadolinium exposure were 0.9-1.2 mg/dL, with a corresponding estimated glomerular filtration rate of 64 mL/min/1.73m2 by modification of diet in renal disease equation. Twenty-four-hour urine creatinine clearance was performed as an outpatient following development of symptoms. This revealed a creatinine clearance of 23 mL/min, suggestive of advanced chronic kidney disease despite an estimated glomerular filtration rate of 64 mL/min/1.73m2 Skin biopsy was positive for sclerosing dermopathy. These findings, in addition to the temporal association with gadolinium exposure, led to the diagnosis of nephrogenic systemic fibrosis.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Magnetic Resonance Imaging
/
Contrast Media
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Nephrogenic Fibrosing Dermopathy
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Gadolinium
Limits:
Female
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Humans
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Middle aged
Language:
En
Journal:
BMJ Case Rep
Year:
2017
Document type:
Article
Affiliation country: