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Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
Rai, Ganesha; Brimacombe, Kyle R; Mott, Bryan T; Urban, Daniel J; Hu, Xin; Yang, Shyh-Ming; Lee, Tobie D; Cheff, Dorian M; Kouznetsova, Jennifer; Benavides, Gloria A; Pohida, Katie; Kuenstner, Eric J; Luci, Diane K; Lukacs, Christine M; Davies, Douglas R; Dranow, David M; Zhu, Hu; Sulikowski, Gary; Moore, William J; Stott, Gordon M; Flint, Andrew J; Hall, Matthew D; Darley-Usmar, Victor M; Neckers, Leonard M; Dang, Chi V; Waterson, Alex G; Simeonov, Anton; Jadhav, Ajit; Maloney, David J.
Affiliation
  • Rai G; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
  • Brimacombe KR; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
  • Mott BT; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
  • Urban DJ; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
  • Hu X; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
  • Yang SM; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
  • Lee TD; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
  • Cheff DM; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
  • Kouznetsova J; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
  • Benavides GA; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham , Birmingham, Alabama 35294, United States.
  • Pohida K; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
  • Kuenstner EJ; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
  • Luci DK; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
  • Lukacs CM; Beryllium Discovery Corp. , 7869 Day Road West, Bainbridge Island, Washington 98110, United States.
  • Davies DR; Beryllium Discovery Corp. , 7869 Day Road West, Bainbridge Island, Washington 98110, United States.
  • Dranow DM; Beryllium Discovery Corp. , 7869 Day Road West, Bainbridge Island, Washington 98110, United States.
  • Zhu H; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
  • Sulikowski G; Vanderbilt Institute of Chemical Biology, Vanderbilt University , Nashville, Tennessee 37232, United States.
  • Moore WJ; NExT Program Support, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research , Frederick, Maryland 21702, United States.
  • Stott GM; NExT Program Support, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research , Frederick, Maryland 21702, United States.
  • Flint AJ; NExT Program Support, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research , Frederick, Maryland 21702, United States.
  • Hall MD; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
  • Darley-Usmar VM; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham , Birmingham, Alabama 35294, United States.
  • Neckers LM; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute , 9000 Rockville Pike, Bethesda, Maryland 20892, United States.
  • Dang CV; Abramson Cancer Center, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania , Philadephia, Pennsylvania 19104, United States.
  • Waterson AG; Vanderbilt Institute of Chemical Biology, Vanderbilt University , Nashville, Tennessee 37232, United States.
  • Simeonov A; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
  • Jadhav A; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
  • Maloney DJ; National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
J Med Chem ; 60(22): 9184-9204, 2017 11 22.
Article in En | MEDLINE | ID: mdl-29120638
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Thiazoles / Enzyme Inhibitors / L-Lactate Dehydrogenase Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2017 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Thiazoles / Enzyme Inhibitors / L-Lactate Dehydrogenase Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2017 Document type: Article Affiliation country: