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Pharmacokinetics, Pharmacodynamics, and Proposed Dosing of the Oral JAK1 and JAK2 Inhibitor Baricitinib in Pediatric and Young Adult CANDLE and SAVI Patients.
Kim, Hanna; Brooks, Kristina M; Tang, Cheng Cai; Wakim, Paul; Blake, Mary; Brooks, Stephen R; Montealegre Sanchez, Gina A; de Jesus, Adriana A; Huang, Yan; Tsai, Wanxia Li; Gadina, Massimo; Prakash, Apurva; Janes, Jonathan Marcus; Zhang, Xin; Macias, William L; Kumar, Parag; Goldbach-Mansky, Raphaela.
Affiliation
  • Kim H; Lawrence Shulman Scholar, Office of the Clinical Director, and Pediatric Translational Research Branch, NIAMS, NIH, Bethesda, Maryland, USA.
  • Brooks KM; Clinical Pharmacokinetics Research Unit, Pharmacy Department, NIH Clinical Center, Bethesda, Maryland, USA.
  • Tang CC; Lilly-NUS Centre for Clinical Pharmacology, Singapore.
  • Wakim P; Biostatistics and Clinical Epidemiology Service, NIH Clinical Center, Bethesda, Maryland, USA.
  • Blake M; Translational Immunology Section, Office of Science and Technology, NIAMS, NIH, Bethesda, Maryland, USA.
  • Brooks SR; Biodata Mining and Discovery Section, Office of Science and Technology, NIAMS, NIH, Bethesda, Maryland, USA.
  • Montealegre Sanchez GA; Translational Autoinflammatory Disease Studies, NIAID, NIH, Bethesda, Maryland, USA.
  • de Jesus AA; Translational Autoinflammatory Disease Studies, NIAID, NIH, Bethesda, Maryland, USA.
  • Huang Y; Translational Autoinflammatory Disease Studies, NIAID, NIH, Bethesda, Maryland, USA.
  • Tsai WL; Translational Immunology Section, Office of Science and Technology, NIAMS, NIH, Bethesda, Maryland, USA.
  • Gadina M; Translational Immunology Section, Office of Science and Technology, NIAMS, NIH, Bethesda, Maryland, USA.
  • Prakash A; Eli Lilly and Co, Indianapolis, Indiana, USA.
  • Janes JM; Eli Lilly and Co, Indianapolis, Indiana, USA.
  • Zhang X; Eli Lilly and Co, Indianapolis, Indiana, USA.
  • Macias WL; Eli Lilly and Co, Indianapolis, Indiana, USA.
  • Kumar P; Clinical Pharmacokinetics Research Unit, Pharmacy Department, NIH Clinical Center, Bethesda, Maryland, USA.
  • Goldbach-Mansky R; Translational Autoinflammatory Disease Studies, NIAID, NIH, Bethesda, Maryland, USA.
Clin Pharmacol Ther ; 104(2): 364-373, 2018 08.
Article in En | MEDLINE | ID: mdl-29134648
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Sulfonamides / Azetidines / Janus Kinase 1 / Janus Kinase 2 / Drug Dosage Calculations / Janus Kinase Inhibitors / Inflammation / Models, Biological Type of study: Diagnostic_studies / Prognostic_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Clin Pharmacol Ther Year: 2018 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Sulfonamides / Azetidines / Janus Kinase 1 / Janus Kinase 2 / Drug Dosage Calculations / Janus Kinase Inhibitors / Inflammation / Models, Biological Type of study: Diagnostic_studies / Prognostic_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Clin Pharmacol Ther Year: 2018 Document type: Article Affiliation country: Country of publication: