Mechanistic Physiologically Based Pharmacokinetic (PBPK) Model of the Heart Accounting for Inter-Individual Variability: Development and Performance Verification.

Tylutki, Zofia; Mendyk, Aleksander; Polak, Sebastian

Tylutki, Zofia; Mendyk, Aleksander; Polak, Sebastian.

Affiliation

Tylutki Z; Unit of Pharmacoepidemiology and Pharmacoeconomics, Department of Social Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 Str., 30-688 Krakow, Poland. Electronic address: zofia.tylutki@doctoral.uj.edu.pl.
Mendyk A; Department of Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, Poland.
Polak S; Unit of Pharmacoepidemiology and Pharmacoeconomics, Department of Social Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 Str., 30-688 Krakow, Poland; Simcyp (a Certara Company) Limited, Blades Enterprise Centre, John Street, Sheffield S2 4SU, UK.

J Pharm Sci ; 107(4): 1167-1177, 2018 04.

Article in En | MEDLINE | ID: mdl-29175411

Subject(s)
Key words

disposition; in silico modeling; pharmacokinetic/pharmacodynamic models; pharmacokinetics; physiological model

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biological Variation, Population / Heart / Amitriptyline / Nortriptyline Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Pharm Sci Year: 2018 Document type: Article

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