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Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.
Bilanges, Benoit; Alliouachene, Samira; Pearce, Wayne; Morelli, Daniele; Szabadkai, Gyorgy; Chung, Yuen-Li; Chicanne, Gaëtan; Valet, Colin; Hill, Julia M; Voshol, Peter J; Collinson, Lucy; Peddie, Christopher; Ali, Khaled; Ghazaly, Essam; Rajeeve, Vinothini; Trichas, Georgios; Srinivas, Shankar; Chaussade, Claire; Salamon, Rachel S; Backer, Jonathan M; Scudamore, Cheryl L; Whitehead, Maria A; Keaney, Erin P; Murphy, Leon O; Semple, Robert K; Payrastre, Bernard; Tooze, Sharon A; Vanhaesebroeck, Bart.
Affiliation
  • Bilanges B; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK. b.bilanges@ucl.ac.uk.
  • Alliouachene S; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
  • Pearce W; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
  • Morelli D; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
  • Szabadkai G; Department of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London, Gower Street, London, WC1E 6BT, UK.
  • Chung YL; Department of Biomedical Sciences, University of Padua, Padua, 58/B via Ugo, Bassi, 35121, Italy.
  • Chicanne G; Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research London, 123 Old Brompton Road, London, SW7 3RP, UK.
  • Valet C; Inserm/UPS UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires, 1 Avenue Jean Poulhès BP 84225, 31432, Toulouse Cedex 4, France.
  • Hill JM; Inserm/UPS UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires, 1 Avenue Jean Poulhès BP 84225, 31432, Toulouse Cedex 4, France.
  • Voshol PJ; Department of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London, Gower Street, London, WC1E 6BT, UK.
  • Collinson L; Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Box 289, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
  • Peddie C; The Francis Crick Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK.
  • Ali K; The Francis Crick Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK.
  • Ghazaly E; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
  • Rajeeve V; Centre of Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
  • Trichas G; Centre of Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
  • Srinivas S; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
  • Chaussade C; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
  • Salamon RS; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
  • Backer JM; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, 10461, NY, USA.
  • Scudamore CL; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, 10461, NY, USA.
  • Whitehead MA; Mary Lyon Centre, MRC Harwell, Harwell Science and Innovation Campus, Harwell, OX11 0RD, UK.
  • Keaney EP; UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
  • Murphy LO; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA.
  • Semple RK; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA.
  • Payrastre B; Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
  • Tooze SA; Inserm/UPS UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires, 1 Avenue Jean Poulhès BP 84225, 31432, Toulouse Cedex 4, France.
  • Vanhaesebroeck B; The Francis Crick Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK.
Nat Commun ; 8(1): 1804, 2017 11 27.
Article in En | MEDLINE | ID: mdl-29180704
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Signal Transduction / Phosphatidylinositol 3-Kinases / Mitochondria Type of study: Diagnostic_studies Limits: Animals / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2017 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Signal Transduction / Phosphatidylinositol 3-Kinases / Mitochondria Type of study: Diagnostic_studies Limits: Animals / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2017 Document type: Article Affiliation country: Country of publication: