Effect of a Carbohydrate-Rich Diet on Rat Detrusor Smooth Muscle Contractility: An Experimental Study.
Biomed Res Int
; 2017: 5796456, 2017.
Article
in En
| MEDLINE
| ID: mdl-29201908
ABSTRACT
OBJECTIVES:
We aimed to investigate the effect of a carbohydrate-rich diet on detrusor contractility in rats. MATERIALS ANDMETHODS:
Sprague-Dawley rats were randomized into two groups. The control group received regular food and water. The study group received carbohydrate-rich diet for six weeks. The rats' detrusor muscle was isolated for pharmacological and histopathological examinations.RESULTS:
In the control and study groups, mean body weights were 431.5 ± 27.6 g and 528.0 ± 36.2 g, respectively (p < 0.001). Electrical stimulation of the detrusor strips of the control group resulted in gradual contraction. A decreased contractile response was shown in the study group. Acetylcholine in 10-7-10-3 molar concentration produced a decreased contractile response in the study group, compared to the control group (p < 0.01). The study group showed marked subepithelial and intermuscular fibrosis in the bladder.CONCLUSION:
Carbohydrate-rich diet causes marked subepithelial and extracellular fibrosis and changes in contractility in the detrusor within a six-week period. Changes have higher costs in therapeutic choices and correction of these changes remains difficult. Putting an end to carbohydrate-rich diet would seem to be more cost-effective than dealing with the effects of consuming it in high proportions which should be the national policy worldwide.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fibrosis
/
Urinary Bladder, Overactive
/
Muscle Contraction
/
Muscle, Smooth
Type of study:
Clinical_trials
Limits:
Animals
/
Humans
Language:
En
Journal:
Biomed Res Int
Year:
2017
Document type:
Article
Affiliation country: