Your browser doesn't support javascript.
loading
Partial rescue of F508del-cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual-acting small molecule.
Liu, Jia; Bihler, Hermann; Farinha, Carlos M; Awatade, Nikhil T; Romão, Ana M; Mercadante, Dayna; Cheng, Yi; Musisi, Isaac; Jantarajit, Walailak; Wang, Yiting; Cai, Zhiwei; Amaral, Margarida D; Mense, Martin; Sheppard, David N.
Affiliation
  • Liu J; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
  • Bihler H; Cystic Fibrosis Foundation Therapeutics, Lexington, MA, USA.
  • Farinha CM; Faculty of Sciences, BioISI - Biosystems and Integrative Sciences Institute, University of Lisboa, Lisboa, Portugal.
  • Awatade NT; Faculty of Sciences, BioISI - Biosystems and Integrative Sciences Institute, University of Lisboa, Lisboa, Portugal.
  • Romão AM; Faculty of Sciences, BioISI - Biosystems and Integrative Sciences Institute, University of Lisboa, Lisboa, Portugal.
  • Mercadante D; Cystic Fibrosis Foundation Therapeutics, Lexington, MA, USA.
  • Cheng Y; Cystic Fibrosis Foundation Therapeutics, Lexington, MA, USA.
  • Musisi I; Cystic Fibrosis Foundation Therapeutics, Lexington, MA, USA.
  • Jantarajit W; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
  • Wang Y; Center of Calcium and Bone Research and Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
  • Cai Z; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
  • Amaral MD; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
  • Mense M; Faculty of Sciences, BioISI - Biosystems and Integrative Sciences Institute, University of Lisboa, Lisboa, Portugal.
  • Sheppard DN; Cystic Fibrosis Foundation Therapeutics, Lexington, MA, USA.
Br J Pharmacol ; 175(7): 1017-1038, 2018 04.
Article in En | MEDLINE | ID: mdl-29318594
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cystic Fibrosis Transmembrane Conductance Regulator Limits: Animals / Humans Language: En Journal: Br J Pharmacol Year: 2018 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cystic Fibrosis Transmembrane Conductance Regulator Limits: Animals / Humans Language: En Journal: Br J Pharmacol Year: 2018 Document type: Article Affiliation country: Country of publication: