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Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors.
Suebsuwong, Chalada; Pinkas, Daniel M; Ray, Soumya S; Bufton, Joshua C; Dai, Bing; Bullock, Alex N; Degterev, Alexei; Cuny, Gregory D.
Affiliation
  • Suebsuwong C; Department of Chemistry, University of Houston, Science and Research Building 2, Houston, TX 77204, USA.
  • Pinkas DM; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK.
  • Ray SS; Stemetix Inc., 604 Webster St., Needham, MA 02494, USA.
  • Bufton JC; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK.
  • Dai B; Department of Developmental, Molecular & Chemical Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
  • Bullock AN; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK.
  • Degterev A; Department of Developmental, Molecular & Chemical Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA. Electronic address: alexei.degterev@tufts.edu.
  • Cuny GD; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Science and Research Building 2, Houston, TX 77204, USA. Electronic address: gdcuny@central.uh.edu.
Bioorg Med Chem Lett ; 28(4): 577-583, 2018 02 15.
Article in En | MEDLINE | ID: mdl-29409752
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylurea Compounds / Pyridines / Protein Kinase Inhibitors / Receptor-Interacting Protein Serine-Threonine Kinase 2 Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylurea Compounds / Pyridines / Protein Kinase Inhibitors / Receptor-Interacting Protein Serine-Threonine Kinase 2 Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Document type: Article Affiliation country: Country of publication: