Optimal designs for active controlled dose-finding trials with efficacy-toxicity outcomes.
Biometrika
; 104(4): 1003-1010, 2017 Dec.
Article
in En
| MEDLINE
| ID: mdl-29430043
ABSTRACT
We derive optimal designs to estimate efficacy and toxicity in active controlled dose-finding trials when the bivariate continuous outcomes are described using nonlinear regression models. We determine upper bounds on the required number of different doses and provide conditions under which the boundary points of the design space are included in the optimal design. We provide an analytical description of minimally supported optimal designs and show that they do not depend on the correlation between the bivariate outcomes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Diagnostic_studies
/
Prognostic_studies
Language:
En
Journal:
Biometrika
Year:
2017
Document type:
Article