Vaccination Against Lawsonia intracellularis Decreases Shedding of Salmonella enterica serovar Typhimurium in Co-Infected Pigs and Alters the Gut Microbiome.
Sci Rep
; 8(1): 2857, 2018 02 12.
Article
in En
| MEDLINE
| ID: mdl-29434295
ABSTRACT
Salmonella enterica serovar Typhimurium continues to be a major cause of foodborne illness worldwide and pork can serve as a source of infection. Co-infection of S. enterica with Lawsonia intracellularis, a common intestinal pathogen of swine, has been found as risk factor for increased S. enterica shedding. The objective of this study was to investigate if vaccination against L. intracellularis could lead to decreased S. Typhimurium shedding. To test this hypothesis, pigs were challenged with either S. Typhimurium or S. Typhimurium and L. intracellularis, with and without L. intracellularis vaccination (n = 9 per group). A non-challenged group served as a negative control. Vaccination decreased the shedding of S. Typhimurium in co-infected animals by 2.12 log10 organisms per gram of feces at 7 days post infection. Analysis of the microbiome showed that vaccination led to changes in the abundance of Clostridium species, including Clostridium butyricum, in addition to other compositional changes that may explain the protection mediated against S. Typhimurium. These results indicate that vaccination against L. intracellularis in co-infected herds may provide a new tool to increase food safety by helping to prevent S. enterica without the need for antibiotics.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Salmonella Infections, Animal
/
Salmonella typhimurium
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Swine Diseases
/
Bacterial Vaccines
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Desulfovibrionaceae Infections
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Bacterial Shedding
/
Gastrointestinal Microbiome
Type of study:
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
Sci Rep
Year:
2018
Document type:
Article
Affiliation country: