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Ouabain suppresses the growth and migration abilities of glioma U­87MG cells through inhibiting the Akt/mTOR signaling pathway and downregulating the expression of HIF­1α.
Yang, Xiao-Sa; Xu, Zhong-Wei; Yi, Tai-Long; Xu, Rui-Cheng; Li, Jie; Zhang, Wen-Bin; Zhang, Sai; Sun, Hong-Tao; Yu, Ze-Qi; Xu, Hao-Xiang; Tu, Yue; Cheng, Shi-Xiang.
Affiliation
  • Yang XS; Institute of TBI and Neuroscience of Chinese People's Armed Police Force, Tianjin Key Laboratory of Neurotrauma Repair, Center for Neurology and Neurosurgery of Affiliated Hospital of Logistics University of PAP, Tianjin 300162, P.R. China.
  • Xu ZW; Central Laboratory of Logistics University of PAP, Tianjin 300309, P.R. China.
  • Yi TL; Institute of TBI and Neuroscience of Chinese People's Armed Police Force, Tianjin Key Laboratory of Neurotrauma Repair, Center for Neurology and Neurosurgery of Affiliated Hospital of Logistics University of PAP, Tianjin 300162, P.R. China.
  • Xu RC; Tianjin Key Laboratory for Biomarkers of Occupational and Environmental Hazard, Logistics University of PAP, Tianjin 300309, P.R. China.
  • Li J; Institute of TBI and Neuroscience of Chinese People's Armed Police Force, Tianjin Key Laboratory of Neurotrauma Repair, Center for Neurology and Neurosurgery of Affiliated Hospital of Logistics University of PAP, Tianjin 300162, P.R. China.
  • Zhang WB; Institute of TBI and Neuroscience of Chinese People's Armed Police Force, Tianjin Key Laboratory of Neurotrauma Repair, Center for Neurology and Neurosurgery of Affiliated Hospital of Logistics University of PAP, Tianjin 300162, P.R. China.
  • Zhang S; Institute of TBI and Neuroscience of Chinese People's Armed Police Force, Tianjin Key Laboratory of Neurotrauma Repair, Center for Neurology and Neurosurgery of Affiliated Hospital of Logistics University of PAP, Tianjin 300162, P.R. China.
  • Sun HT; Institute of TBI and Neuroscience of Chinese People's Armed Police Force, Tianjin Key Laboratory of Neurotrauma Repair, Center for Neurology and Neurosurgery of Affiliated Hospital of Logistics University of PAP, Tianjin 300162, P.R. China.
  • Yu ZQ; Institute of TBI and Neuroscience of Chinese People's Armed Police Force, Tianjin Key Laboratory of Neurotrauma Repair, Center for Neurology and Neurosurgery of Affiliated Hospital of Logistics University of PAP, Tianjin 300162, P.R. China.
  • Xu HX; Institute of TBI and Neuroscience of Chinese People's Armed Police Force, Tianjin Key Laboratory of Neurotrauma Repair, Center for Neurology and Neurosurgery of Affiliated Hospital of Logistics University of PAP, Tianjin 300162, P.R. China.
  • Tu Y; Institute of TBI and Neuroscience of Chinese People's Armed Police Force, Tianjin Key Laboratory of Neurotrauma Repair, Center for Neurology and Neurosurgery of Affiliated Hospital of Logistics University of PAP, Tianjin 300162, P.R. China.
  • Cheng SX; Institute of TBI and Neuroscience of Chinese People's Armed Police Force, Tianjin Key Laboratory of Neurotrauma Repair, Center for Neurology and Neurosurgery of Affiliated Hospital of Logistics University of PAP, Tianjin 300162, P.R. China.
Mol Med Rep ; 17(4): 5595-5600, 2018 04.
Article in En | MEDLINE | ID: mdl-29436645
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ouabain / Signal Transduction / Gene Expression Regulation, Neoplastic / Proto-Oncogene Proteins c-akt / Hypoxia-Inducible Factor 1, alpha Subunit / TOR Serine-Threonine Kinases / Glioma Limits: Humans Language: En Journal: Mol Med Rep Year: 2018 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ouabain / Signal Transduction / Gene Expression Regulation, Neoplastic / Proto-Oncogene Proteins c-akt / Hypoxia-Inducible Factor 1, alpha Subunit / TOR Serine-Threonine Kinases / Glioma Limits: Humans Language: En Journal: Mol Med Rep Year: 2018 Document type: Article Country of publication: