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Supercritical fluid chromatography-photodiode array detection-electrospray ionization mass spectrometry as a framework for impurity fate mapping in the development and manufacture of drug substances.
Pirrone, Gregory F; Mathew, Rose M; Makarov, Alexey A; Bernardoni, Frank; Klapars, Artis; Hartman, Robert; Limanto, John; Regalado, Erik L.
Affiliation
  • Pirrone GF; Process Research and Development, MRL, Merck & Co., Inc., Rahway, NJ 07065, USA.
  • Mathew RM; Process Research and Development, MRL, Merck & Co., Inc., Rahway, NJ 07065, USA.
  • Makarov AA; Process Research and Development, MRL, Merck & Co., Inc., Rahway, NJ 07065, USA.
  • Bernardoni F; Process Research and Development, MRL, Merck & Co., Inc., Rahway, NJ 07065, USA.
  • Klapars A; Process Research and Development, MRL, Merck & Co., Inc., Rahway, NJ 07065, USA.
  • Hartman R; Process Research and Development, MRL, Merck & Co., Inc., Rahway, NJ 07065, USA.
  • Limanto J; Process Research and Development, MRL, Merck & Co., Inc., Rahway, NJ 07065, USA.
  • Regalado EL; Process Research and Development, MRL, Merck & Co., Inc., Rahway, NJ 07065, USA. Electronic address: erik.regalado@merck.com.
J Chromatogr B Analyt Technol Biomed Life Sci ; 1080: 42-49, 2018 Mar 30.
Article in En | MEDLINE | ID: mdl-29477066
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmaceutical Preparations / Chemistry, Pharmaceutical / Drug Contamination / Spectrometry, Mass, Electrospray Ionization / Chromatography, Supercritical Fluid Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: J Chromatogr B Analyt Technol Biomed Life Sci Journal subject: ENGENHARIA BIOMEDICA Year: 2018 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmaceutical Preparations / Chemistry, Pharmaceutical / Drug Contamination / Spectrometry, Mass, Electrospray Ionization / Chromatography, Supercritical Fluid Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: J Chromatogr B Analyt Technol Biomed Life Sci Journal subject: ENGENHARIA BIOMEDICA Year: 2018 Document type: Article Affiliation country: