Comparison of computer-aided detection (CADe) capability for pulmonary nodules among standard-, reduced- and ultra-low-dose CTs with and without hybrid type iterative reconstruction technique.
Eur J Radiol
; 100: 49-57, 2018 Mar.
Article
in En
| MEDLINE
| ID: mdl-29496079
ABSTRACT
PURPOSE:
To directly compare the effect of a reconstruction algorithm on nodule detection capability of the computer-aided detection (CADe) system using standard-dose, reduced-dose and ultra-low dose chest CTs with and without adaptive iterative dose reduction 3D (AIDR 3D). MATERIALS ANDMETHODS:
Our institutional review board approved this study, and written informed consent was obtained from each patient. Standard-, reduced- and ultra-low-dose chest CTs (250â¯mA, 50â¯mA and 10â¯mA) were used to examine 40 patients, 21 males (mean age⯱â¯standard deviation 63.1⯱â¯11.0â¯years) and 19 females (mean age, 65.1⯱â¯12.7â¯years), and reconstructed as 1 mm-thick sections. Detection of nodule equal to more than 4â¯mm in dimeter was automatically performed by our proprietary CADe software. The utility of iterative reconstruction method for improving nodule detection capability, sensitivity and false positive rate (/case) of the CADe system using all protocols were compared by means of McNemar's test or signed rank test.RESULTS:
Sensitivity (SE 0.43) and false-positive rate (FPR 7.88) of ultra-low-dose CT without AIDR 3D was significantly inferior to those of standard-dose CTs (with AIDR 3D SE, 0.78, pâ¯<â¯.0001, FPR, 3.05, pâ¯<â¯.0001; and without AIDR 3D SE, 0.80, pâ¯<â¯.0001, FPR 2.63, pâ¯<â¯.0001), reduced-dose CTs (with AIDR 3D SE, 0.81, pâ¯<â¯.0001, FPR, 3.05, pâ¯<â¯.0001; and without AIDR 3D SE, 0.62, pâ¯<â¯.0001, FPR 2.95, pâ¯<â¯.0001) and ultra-low-dose CT with AIDR 3D (SE, 0.79, pâ¯<â¯.0001, FPR, 4.88, pâ¯=â¯.0001).CONCLUSION:
The AIDR 3D has a significant positive effect on nodule detection capability of the CADe system even when radiation dose is reduced.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Radiation Dosage
/
Radiographic Image Interpretation, Computer-Assisted
/
Tomography, X-Ray Computed
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Imaging, Three-Dimensional
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Multiple Pulmonary Nodules
/
Lung Neoplasms
Type of study:
Diagnostic_studies
/
Observational_studies
Limits:
Adult
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Aged
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Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Eur J Radiol
Year:
2018
Document type:
Article