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Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC).
Zhang, Maofeng; Zhang, Yan; Song, Ming; Xue, Xiaoqian; Wang, Junjian; Wang, Chao; Zhang, Cheng; Li, Chenchang; Xiang, Qiuping; Zou, Lingjiao; Wu, Xishan; Wu, Chun; Dong, Baijun; Xue, Wei; Zhou, Yulai; Chen, Hongwu; Wu, Donghai; Ding, Ke; Xu, Yong.
Affiliation
  • Zhang M; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ; Guangzhou Medical University , Guangzhou , China.
  • Zhang Y; University of Chinese Academy of Sciences , No. 19 Yuquan Road , Beijing 100049 , China.
  • Song M; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ; Guangzhou Medical University , Guangzhou , China.
  • Xue X; University of Chinese Academy of Sciences , No. 19 Yuquan Road , Beijing 100049 , China.
  • Wang J; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ; Guangzhou Medical University , Guangzhou , China.
  • Wang C; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ; Guangzhou Medical University , Guangzhou , China.
  • Zhang C; University of Chinese Academy of Sciences , No. 19 Yuquan Road , Beijing 100049 , China.
  • Li C; Department of Biochemistry and Molecular Medicine, School of Medicine , University of California, Davis , Sacramento , California 95817 , United States.
  • Xiang Q; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ; Guangzhou Medical University , Guangzhou , China.
  • Zou L; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ; Guangzhou Medical University , Guangzhou , China.
  • Wu X; School of Pharmaceutical Sciences , Jilin University , No. 1266 Fujin Road , Chaoyang District, Changchun , Jilin 130021 , China.
  • Wu C; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ; Guangzhou Medical University , Guangzhou , China.
  • Dong B; School of Pharmaceutical Sciences , Jilin University , No. 1266 Fujin Road , Chaoyang District, Changchun , Jilin 130021 , China.
  • Xue W; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ; Guangzhou Medical University , Guangzhou , China.
  • Zhou Y; University of Chinese Academy of Sciences , No. 19 Yuquan Road , Beijing 100049 , China.
  • Chen H; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ; Guangzhou Medical University , Guangzhou , China.
  • Wu D; University of Chinese Academy of Sciences , No. 19 Yuquan Road , Beijing 100049 , China.
  • Ding K; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ; Guangzhou Medical University , Guangzhou , China.
  • Xu Y; University of Chinese Academy of Sciences , No. 19 Yuquan Road , Beijing 100049 , China.
J Med Chem ; 61(7): 3037-3058, 2018 04 12.
Article in En | MEDLINE | ID: mdl-29566488
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteins / Prostatic Neoplasms, Castration-Resistant / Isoxazoles / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteins / Prostatic Neoplasms, Castration-Resistant / Isoxazoles / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: Country of publication: