PSPC1 mediates TGF-ß1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis.
Nat Cell Biol
; 20(4): 479-491, 2018 04.
Article
in En
| MEDLINE
| ID: mdl-29593326
ABSTRACT
Activation of metastatic reprogramming is critical for tumour metastasis. However, more detailed knowledge of the underlying mechanism is needed to enable targeted intervention. Here, we show that paraspeckle component 1 (PSPC1), identified in an aberrant 13q12.11 locus, is upregulated and associated with poor survival in patients with cancer. PSPC1 promotes tumorigenesis, epithelial-to-mesenchymal transition (EMT), stemness and metastasis in multiple cell types and in spontaneous mouse cancer models. PSPC1 is the master activator for transcription factors of EMT and stemness and accompanies c-Myc activation to facilitate tumour growth. PSPC1 increases transforming growth factor-ß1 (TGF-ß1) secretion through an interaction with phosphorylated and nuclear Smad2/3 to potentiate TGF-ß1 autocrine signalling. Moreover, PSPC1 acts as a contextual determinant of the TGF-ß1 pro-metastatic switch to alter Smad2/3 binding preference from tumour-suppressor to pro-metastatic genes. Having validated the PSPC1-Smads-TGF-ß1 axis in various cancers, we conclude that PSPC1 is a master activator of pro-metastatic switches and a potential target for anti-metastasis drugs.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neoplastic Stem Cells
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Nuclear Proteins
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Signal Transduction
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Cell Movement
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RNA-Binding Proteins
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Autocrine Communication
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Smad2 Protein
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Smad3 Protein
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Transforming Growth Factor beta1
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Epithelial-Mesenchymal Transition
Type of study:
Prognostic_studies
Limits:
Animals
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Female
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Humans
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Male
Language:
En
Journal:
Nat Cell Biol
Year:
2018
Document type:
Article
Affiliation country: