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Impact of intranasal application of nerve growth factor on the olfactory epithelium in rats with chemically induced diabetes.
Yalim, Sidika; Daglioglu, Kenan; Coskun, Gülfidan; Polat, Sait.
Affiliation
  • Yalim S; a Department of Otorhinolaryngology Head and Neck Surgery , Adana City Training and Research Hospital , Adana , Turkey.
  • Daglioglu K; b Experimental Research and Application Center of Medical Sciences , Cukurova University , Adana , Turkey.
  • Coskun G; c Department of Histology and Embryology , Cukurova Medical Faculty, Cukurova University , Adana , Turkey.
  • Polat S; c Department of Histology and Embryology , Cukurova Medical Faculty, Cukurova University , Adana , Turkey.
Ultrastruct Pathol ; 42(3): 246-254, 2018.
Article in En | MEDLINE | ID: mdl-29693500
ABSTRACT
Recent studies suggest that nerve growth factor (NGF) protects olfactory cells and axons from injury in vitro. Eighteen Wistar-Albino rats randomly divided into three groups control group, diabetic group without NGF, and diabetic with NGF. Intranasal NGF (6 µg/day) was administered over a 5-day period. At the end of 30 days, the olfactory epithelium (OE) of NGF-applied diabetic rats regenerated, the epithelium thickness was significantly higher, and caspase-3 expression was not significantly different from the control. The current results demonstrate that intranasally administered NGF significantly reversed OE morphological changes in diabetes by decreasing diabetes-related cell death and inflammation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Olfactory Mucosa / Nerve Growth Factor / Diabetes Complications Limits: Animals Language: En Journal: Ultrastruct Pathol Year: 2018 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Olfactory Mucosa / Nerve Growth Factor / Diabetes Complications Limits: Animals Language: En Journal: Ultrastruct Pathol Year: 2018 Document type: Article Affiliation country: