Cinnamaldehyde protects VSMCs against ox-LDL-induced proliferation and migration through S arrest and inhibition of p38, JNK/MAPKs and NF-κB.
Vascul Pharmacol
; 108: 57-66, 2018 09.
Article
in En
| MEDLINE
| ID: mdl-29777873
ABSTRACT
Cinnamaldehyde (Cin), as a traditional flavor constituent isolated from the bark of Cinnamonum cassia Presl, has been commonly used for - digestive, cardiovascular and immune system diseases. The pathology of vascular smooth muscle cells (VSMCs) accelerated the progression of atherosclerosis. In our study, we found that cinnamaldehyde significantly suppressed ox-LDL-induced VSMCs proliferation, migration and inflammatory cytokine overproduction, as well as foam cell formation in VSMCs and macrophages. Moreover, cinnamaldehyde inhibited the phosphorylation of p38, JNK and p65 NF-κB and increased heme oxygenase-1 (HO-1) activity. In addition, cinnamaldehyde reduced monocyte chemotactic protein-1 (MCP-1), matrix metalloproteinase-2 (MMP-2) and lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) expression. Furthermore, cinnamaldehyde arrested cell cycle in S phase. Thus, results indicated that cinnamaldehyde antagonized the ox-LDL-induced VSMCs proliferation, migration, inflammation and foam cell formation through regulation of HO-1, MMP-2, LOX-1 and blockage of cell cycle, and - suppression of p38, JNK/MAPK and NF-κB signaling pathways.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acrolein
/
Cell Movement
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Myocytes, Smooth Muscle
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JNK Mitogen-Activated Protein Kinases
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P38 Mitogen-Activated Protein Kinases
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Cell Proliferation
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Transcription Factor RelA
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S Phase Cell Cycle Checkpoints
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Lipoproteins, LDL
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Anti-Inflammatory Agents
Limits:
Animals
Language:
En
Journal:
Vascul Pharmacol
Journal subject:
ANGIOLOGIA
/
FARMACOLOGIA
Year:
2018
Document type:
Article