Controlled attenuation parameter in NAFLD identifies risk of suboptimal glycaemic and metabolic control.
J Diabetes Complications
; 32(8): 799-804, 2018 Aug.
Article
in En
| MEDLINE
| ID: mdl-29861312
ABSTRACT
AIMS:
To examine the relationship between steatosis quantified by controlled attenuation parameter (CAP) values and glycaemic/metabolic control.METHODS:
230 patients, recruited from an Endocrine clinic or primary care underwent routine Hepatology assessment, with liver stiffness measurements and simultaneous CAP. Multivariable logistic regression was performed to identify potential predictors of Metabolic Syndrome (MetS), HbA1câ¯≥â¯7%, use of insulin, hypertriglyceridaemia and CAPâ¯≥â¯300â¯dB/m.RESULTS:
Patients were 56.7⯱â¯12.3â¯years of age with a high prevalence of MetS (83.5%), T2DM (81.3%), and BMIâ¯≥â¯40â¯kg/m2 (18%). Median CAP score was 344â¯dB/m, ranging from 128 to 400â¯dB/m. BMI (aOR 1.140 95% CI 1.068-1.216), requirement for insulin (aOR 2.599 95% CI 1.212-5.575), and serum ALT (aOR 1.018 95% CI 1.004-1.033) were independently associated with CAPâ¯≥â¯300â¯dB/m. Patients with CAP interquartile rangeâ¯<â¯40 (68%) had a higher median serum ALT level (pâ¯=â¯0.029), greater prevalence of BMIâ¯≥â¯40â¯kg/m2 (pâ¯=â¯0.020) and higher median CAP score (pâ¯<â¯0.001). Patients with higher CAP scores were more likely to have MetS (aOR 1.011 95% CI 1.003-1.019), HBA1câ¯≥â¯7 (aOR 1.010 95% CI 1.003-1.016), requirement for insulin (aOR 1.007 95% CI 1.002-1.013) and hypertriglyceridemia (aOR 1.007 95% CI 1.002-1.013).CONCLUSIONS:
Our data demonstrate that an elevated CAP reflects suboptimal metabolic control. In diabetic patients with NAFLD, CAP may be a useful point-of-care test to identify patients at risk of poorly controlled metabolic comorbidities or advanced diabetes.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Glycated Hemoglobin
/
Metabolic Syndrome
/
Non-alcoholic Fatty Liver Disease
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Diabetes Complications
Journal subject:
ENDOCRINOLOGIA
Year:
2018
Document type:
Article
Affiliation country: