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Isoscoparins R and S, two new ent-clerodane diterpenoids from Isodon scoparius.
Li, Xing-Ren; Fu, Qiang; Zhou, Min; Hu, Kun; Du, Xue; Li, Xiao-Nian; Sun, Han-Dong; Yue, Jian-Bo; Zhang, Hong-Bin; Puno, Pema-Tenzin.
Affiliation
  • Li XR; Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University , Kunming 650091 , China.
  • Fu Q; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
  • Zhou M; Department of Biomedical Sciences, City University of Hong Kong, Kowloon Tong , Hong Kong , China.
  • Hu K; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
  • Du X; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
  • Li XN; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
  • Sun HD; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
  • Yue JB; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
  • Zhang HB; Department of Biomedical Sciences, City University of Hong Kong, Kowloon Tong , Hong Kong , China.
  • Puno PT; Shenzhen Research Institute of City University of Hong Kong , Shenzhen 518057 , China.
J Asian Nat Prod Res ; 21(10): 977-984, 2019 Oct.
Article in En | MEDLINE | ID: mdl-29873248
ABSTRACT
Two new ent-clerodane diterpenoids, named isoscoparins R and S (1 and 2), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HRESIMS data, and the relative configuration of compound 1 was determined by single-crystal X-ray diffraction. Compound 2 showed weak activity as an autophagic inhibitor.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Isodon / Diterpenes, Clerodane Limits: Humans Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2019 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Isodon / Diterpenes, Clerodane Limits: Humans Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2019 Document type: Article Affiliation country: