C-reactive protein as a predictor of posttraumatic stress induced by acute myocardial infarction.
Gen Hosp Psychiatry
; 53: 125-130, 2018.
Article
in En
| MEDLINE
| ID: mdl-29880326
ABSTRACT
BACKGROUND:
Acute coronary syndrome (ACS) may cause clinically relevant posttraumatic stress disorder symptoms (PTSS). An inflammatory state might be one mechanism linking PTSS with poor prognosis after ACS. We tested the hypothesis that a change in C-reactive protein (CRP) between hospital admission and 3-month follow-up is an independent predictor of ACS-triggered PTSS.METHODS:
We assessed 183 patients (median age 59â¯years; 84% men) with verified myocardial infarction (MI) within 48â¯h of an acute coronary intervention and three months post-MI for self-rated PTSS. 14 (7.7%) patients fulfilled definition criteria for PTSS caseness. CRP values were categorized according to the predicted risk of cardiovascular disease (CVD) at hospital admission (acute inflammatory response) 0 to <5â¯mg/L, 5 to <10â¯mg/L, 10 to <20â¯mg/L, andâ¯≥â¯20 mg/L; and at 3-month follow-up (low-grade inflammation) 0 to <1â¯mg/L, 1 to <3â¯mg/L, andâ¯≥â¯3â¯mg/L. Additionally, in a subsample of 84 patients with CRP levels below 20 mg/L at admission, CRP values were log-transformed.RESULTS:
After adjustment for covariates, less of a reduction or an increase of log CRP values between admission and 3-month follow-up predicted PTSS caseness (OR 6.25, 95% CI 1.25, 31.38), and continuous PTSS (unstandardized Bâ¯=â¯0.21, 95% CI 0.07, 4.19; pâ¯=â¯0.043). Less reduction in CRP risk categories predicted both PTSS caseness (OR 4.14, 95% CI 1.89, 9.06) and continuous PTSS (Bâ¯=â¯1.80, 95% CI 1.09, 2.51; pâ¯<â¯0.001).CONCLUSIONS:
Persistently heightened inflammation seems to be predictive for the development of PTSS three months after ACS, so interventions to lower inflammation might be warranted.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stress Disorders, Post-Traumatic
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C-Reactive Protein
/
Inflammation
/
Myocardial Infarction
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
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Humans
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Male
/
Middle aged
Language:
En
Journal:
Gen Hosp Psychiatry
Year:
2018
Document type:
Article
Affiliation country: