High-Content Optical Codes for Protecting Rapid Diagnostic Tests from Counterfeiting.
Anal Chem
; 90(12): 7383-7390, 2018 06 19.
Article
in En
| MEDLINE
| ID: mdl-29882657
ABSTRACT
Warnings and reports on counterfeit diagnostic devices are released several times a year by regulators and public health agencies. Unfortunately, mishandling, altering, and counterfeiting point-of-care diagnostics (POCDs) and rapid diagnostic tests (RDTs) is lucrative, relatively simple and can lead to devastating consequences. Here, we demonstrate how to implement optical security codes in silicon- and nitrocellulose-based flow paths for device authentication using a smartphone. The codes are created by inkjet spotting inks directly on nitrocellulose or on micropillars. Codes containing up to 32 elements per mm2 and 8 colors can encode as many as 1045 combinations. Codes on silicon micropillars can be erased by setting a continuous flow path across the entire array of code elements or for nitrocellulose by simply wicking a liquid across the code. Static or labile code elements can further be formed on nitrocellulose to create a hidden code using poly(ethylene glycol) (PEG) or glycerol additives to the inks. More advanced codes having a specific deletion sequence can also be created in silicon microfluidic devices using an array of passive routing nodes, which activate in a particular, programmable sequence. Such codes are simple to fabricate, easy to view, and efficient in coding information; they can be ideally used in combination with information on a package to protect diagnostic devices from counterfeiting.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diagnostic Tests, Routine
/
Equipment and Supplies
/
Smartphone
/
Ink
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Anal Chem
Year:
2018
Document type:
Article