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Lingonberry Extract Provides Neuroprotection by Regulating the Purinergic System and Reducing Oxidative Stress in Diabetic Rats.
Reichert, Karine Paula; Schetinger, Maria Rosa Chitolina; Gutierres, Jessie Martins; Pelinson, Luana Paula; Stefanello, Naiara; Dalenogare, Diéssica Padilha; Baldissarelli, Jucimara; Lopes, Thauan Faccin; Morsch, Vera Maria.
Affiliation
  • Reichert KP; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria, RS, 97105-900, Brazil.
  • Schetinger MRC; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria, RS, 97105-900, Brazil.
  • Gutierres JM; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria, RS, 97105-900, Brazil.
  • Pelinson LP; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria, RS, 97105-900, Brazil.
  • Stefanello N; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria, RS, 97105-900, Brazil.
  • Dalenogare DP; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria, RS, 97105-900, Brazil.
  • Baldissarelli J; Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, RS, 96160-000, Brazil.
  • Lopes TF; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria, RS, 97105-900, Brazil.
  • Morsch VM; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria, RS, 97105-900, Brazil.
Mol Nutr Food Res ; 62(16): e1800050, 2018 08.
Article in En | MEDLINE | ID: mdl-29888863
ABSTRACT
SCOPE Beneficial effects produced by polyphenolic compounds are used in the treatment of various diseases, including diabetes. Thus it is relevant to investigate the protective effect of lingonberry extract (LB) on the activities of nucleoside triphosphate diphosphohydrolase (NTPDase), 5'-nucleotidase (5'-NT), and adenosine deaminase (ADA); the density of A1, A2A, and P2×7 receptors; production of reactive species (RS); and the levels of thiobarbituric acid reactive substances (TBARS) in the cerebral cortex of streptozotocin-induced diabetic rats. METHODS AND

RESULTS:

Animals were divided into five groups (n = 10) control/saline; control/LB 50 mg kg-1 ; diabetic/saline; diabetic/LB 25 mg kg-1 ; and diabetic/LB 50 mg kg-1 ; and treated for 30 days. Our results demonstrate that the treatment with LB increased NTPDase activity in the diabetic/LB 50 group compared to diabetic/saline group. Western blot analysis showed that LB restored the density of purinergic receptors to the approximate values of the control/saline group. An increase in the levels of RS and TBARS was observed in the diabetic/saline group compared with the control/saline group, and treatment with LB can prevent this increase.

CONCLUSION:

This study showed that LB could reverse the modifications found in the diabetic state, suggesting that lingonberry may be a coadjuvant in the treatment of diabetes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Extracts / Receptors, Purinergic / Oxidative Stress / Neuroprotective Agents / Vaccinium vitis-idaea / Diabetes Mellitus, Experimental / Aminohydrolases Limits: Animals Language: En Journal: Mol Nutr Food Res Journal subject: CIENCIAS DA NUTRICAO Year: 2018 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Extracts / Receptors, Purinergic / Oxidative Stress / Neuroprotective Agents / Vaccinium vitis-idaea / Diabetes Mellitus, Experimental / Aminohydrolases Limits: Animals Language: En Journal: Mol Nutr Food Res Journal subject: CIENCIAS DA NUTRICAO Year: 2018 Document type: Article Affiliation country: