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Limbic encephalitis as a relapse of Whipple's disease with digestive involvement and spondylodiscitis.
Brönnimann, Didier; Vareil, Marc-Olivier; Sibon, Igor; Lagier, Jean-Christophe; Lepidi, Hubert; Puges, Mathilde; Haneche, Fatiha; Raoult, Didier; Desclaux, Arnaud; Neau, Didier; Cazanave, Charles.
Affiliation
  • Brönnimann D; Service de médecine interne et pathologies infectieuses, CHU de Bordeaux, Groupe Hospitalier Saint André, hôpital Saint André, 1 rue Jean Burguet, 33000, Bordeaux Cedex, France. didier.bronnimann@chu-bordeaux.fr.
  • Vareil MO; Service de maladies infectieuses et dermatologie, Centre hospitalier de la côte basque, 64100, Bayonne, France.
  • Sibon I; CHU Bordeaux, Unité Neurovasculaire, 33000, Bordeaux, France.
  • Lagier JC; Univ. Bordeaux, INCIA UMR CNRS 5287, 33000, Bordeaux, France.
  • Lepidi H; Aix Marseille Université, URMITE, UM 63, CNRS 7278, IRD 198, INSERM 1095, 13000, Marseille, France.
  • Puges M; Aix Marseille Université, URMITE, UM 63, CNRS 7278, IRD 198, INSERM 1095, 13000, Marseille, France.
  • Haneche F; Service des pathologies infectieuses et tropicales, CHU de Bordeaux, hôpital Pellegrin, 33000, Bordeaux, France.
  • Raoult D; Service des pathologies infectieuses et tropicales, CHU de Bordeaux, hôpital Pellegrin, 33000, Bordeaux, France.
  • Desclaux A; Aix Marseille Université, URMITE, UM 63, CNRS 7278, IRD 198, INSERM 1095, 13000, Marseille, France.
  • Neau D; Service des pathologies infectieuses et tropicales, CHU de Bordeaux, hôpital Pellegrin, 33000, Bordeaux, France.
  • Cazanave C; Service des pathologies infectieuses et tropicales, CHU de Bordeaux, hôpital Pellegrin, 33000, Bordeaux, France.
Infection ; 47(4): 637-641, 2019 Aug.
Article in En | MEDLINE | ID: mdl-29987509
ABSTRACT

INTRODUCTION:

Many clinical manifestations can be related to Tropheryma whipplei infection. CASE REPORT We report a Tropheryma whipplei limbic encephalitis developed as a relapse of classical Whipple's disease.

DISCUSSION:

This case is to the best of our knowledge the first proof of the effective brain-blood barrier crossing of both doxycycline and hydroxychloroquine as demonstrated by direct concentration monitoring on brain biopsy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Limbic Encephalitis / Tropheryma / Whipple Disease Limits: Humans / Male / Middle aged Language: En Journal: Infection Year: 2019 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Limbic Encephalitis / Tropheryma / Whipple Disease Limits: Humans / Male / Middle aged Language: En Journal: Infection Year: 2019 Document type: Article Affiliation country: