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Pilot Study of Probe-based Confocal Laser Endomicroscopy with Fluorescein-dripping Method for Liver Tumors.
Morimoto, Masaki; Honjo, Soichiro; Sakamoto, Teruhisa; Uchinaka, E I; Amisaki, Masataka; Arai, Yosuke; Yamamoto, Manabu; Fukumoto, Yoji; Osaki, Tomohiro; Tokuyasu, Naruo; Ashida, Keigo; Saito, Hiroaki; Fujiwara, Yoshiyuki.
Affiliation
  • Morimoto M; Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, Yonago, Japan.
  • Honjo S; Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, Yonago, Japan honjo@tottori-u.ac.jp.
  • Sakamoto T; Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, Yonago, Japan.
  • Uchinaka EI; Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, Yonago, Japan.
  • Amisaki M; Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, Yonago, Japan.
  • Arai Y; Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, Yonago, Japan.
  • Yamamoto M; Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, Yonago, Japan.
  • Fukumoto Y; Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, Yonago, Japan.
  • Osaki T; Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, Yonago, Japan.
  • Tokuyasu N; Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, Yonago, Japan.
  • Ashida K; Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, Yonago, Japan.
  • Saito H; Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, Yonago, Japan.
  • Fujiwara Y; Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Tottori University, Yonago, Japan.
Anticancer Res ; 38(8): 4775-4781, 2018 Aug.
Article in En | MEDLINE | ID: mdl-30061248
BACKGROUND/AIM: Probe-based confocal laser endomicroscopy (pCLE) is a novel diagnostic technique that can provide real-time imaging of tissues at the cellular level. In this study, pCLE was applied to liver tumors and its diagnostic value was evaluated. PATIENTS AND METHODS: Ten patients who underwent hepatectomy for liver tumors were evaluated with pCLE from February to May 2017. Immediately after liver resection, pCLE evaluation was performed in the operating room as an ex vivo study. The newly-adopted "fluorescein-dripping method" was used for the observation. RESULTS: First, the optimal fluorescein exposure time for the surface of liver was defined in the fluorescein-dripping method. Next, the distinctive findings in the cancerous region were investigated. The characteristic appearance of irregular arrangements of concentrated cells under fluorescein dripping was observed in six of seven hepatocellular carcinoma (HCC) tumors. CONCLUSION: In all HCC specimens, discrimination of the cancerous region from normal liver was possible with pCLE.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staining and Labeling / Carcinoma, Hepatocellular / Fluoresceins / Liver / Liver Neoplasms Type of study: Diagnostic_studies / Observational_studies Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Anticancer Res Year: 2018 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staining and Labeling / Carcinoma, Hepatocellular / Fluoresceins / Liver / Liver Neoplasms Type of study: Diagnostic_studies / Observational_studies Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Anticancer Res Year: 2018 Document type: Article Affiliation country: Country of publication: