Prognostic significance of the fibrinogen-to-albumin ratio in gallbladder cancer patients.
World J Gastroenterol
; 24(29): 3281-3292, 2018 Aug 07.
Article
in En
| MEDLINE
| ID: mdl-30090008
ABSTRACT
AIM:
To investigate the prognostic role of fibrinogen-to-albumin ratio (FAR) on patients with gallbladder cancer (GBC) in this study.METHODS:
One hundred and fifty-four GBC patients were retrospectively analyzed, who received potentially curative cholecystectomy in our institute from March 2005 to December 2017. Receiver operating characteristic curve (ROC curve) was used to determine the optimal cut-offs for these biomarkers. In addition, Kaplan-Meier survival analysis as well as multivariate analysis were applied for prognostic analyses.RESULTS:
ROC curve revealed that the optimal cut-off value for FAR was 0.08. FAR was significantly correlated with age (P = 0.045), jaundice (P < 0.001), differentiation (P = 0.002), resection margin status (P < 0.001), T stage (P < 0.001), TNM stage (P < 0.001), and CA199 (P < 0.001) as well as albumin levels (P < 0.001). Multivariate analysis indicated that the resection margin status [hazard ratio (HR) 2.343, 95% confidence interval (CI) 1.532-3.581, P < 0.001], TNM stage (P = 0.035), albumin level (HR = 0.595, 95%CI 0.385-0.921, P = 0.020) and FAR (HR 2.813, 95%CI 1.765-4.484, P < 0.001) were independent prognostic factors in GBC patients.CONCLUSION:
An elevated preoperative FAR was significantly correlated with unfavorable overall survival in GBC patients, while an elevated preoperative albumin level was a protective prognostic factor for patients with GBC. The preoperative FAR could be used to predict the prognosis of GBC patients, which was easily accessible, cost-effective and noninvasive.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fibrinogen
/
Serum Albumin
/
Biomarkers, Tumor
/
Gallbladder Neoplasms
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
World J Gastroenterol
Journal subject:
GASTROENTEROLOGIA
Year:
2018
Document type:
Article
Affiliation country: