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Discovery, characterization, and remediation of a C-terminal Fc-extension in proteins expressed in CHO cells.
Spahr, Christopher S; Daris, Mark E; Graham, Kevin C; Soriano, Brian D; Stevens, Jennitte L; Shi, Stone D-H.
Affiliation
  • Spahr CS; a Discovery Attribute Sciences, Therapeutic Discovery , Amgen Discovery Research , Thousand Oaks , CA , USA.
  • Daris ME; b Biologics Optimization, Therapeutic Discovery , Amgen Discovery Research , Thousand Oaks , CA , USA.
  • Graham KC; b Biologics Optimization, Therapeutic Discovery , Amgen Discovery Research , Thousand Oaks , CA , USA.
  • Soriano BD; a Discovery Attribute Sciences, Therapeutic Discovery , Amgen Discovery Research , Thousand Oaks , CA , USA.
  • Stevens JL; b Biologics Optimization, Therapeutic Discovery , Amgen Discovery Research , Thousand Oaks , CA , USA.
  • Shi SD; a Discovery Attribute Sciences, Therapeutic Discovery , Amgen Discovery Research , Thousand Oaks , CA , USA.
MAbs ; 10(8): 1291-1300, 2018.
Article in En | MEDLINE | ID: mdl-30148415
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Immunoglobulin Fc Fragments / Protein Processing, Post-Translational / Antibodies, Monoclonal Limits: Animals / Humans Language: En Journal: MAbs Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Immunoglobulin Fc Fragments / Protein Processing, Post-Translational / Antibodies, Monoclonal Limits: Animals / Humans Language: En Journal: MAbs Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Document type: Article Affiliation country: