Expression of Stem Cell Factor in Feline Mast Cell Tumour.
J Comp Pathol
; 163: 6-9, 2018 Aug.
Article
in En
| MEDLINE
| ID: mdl-30213375
ABSTRACT
Stem cell factor (SCF) is a ligand of the molecule Kit, which is expressed in mast cells and is important for mast cell proliferation, migration and survival. Mast cell tumours (MCTs) are associated with mutations of c-kit, a proto-oncogene encoding the Kit protein. In this study, we examined SCF expression in 23 samples of feline MCTs. SCF expression was detected in 10 cutaneous MCTs and a case of splenic mastocytosis. In the cutaneous MCTs, SCF-positive tumour cells were located at the margins. Kit was expressed in eight of the 10 cutaneous cases of SCF-expressing MCTs. In these cases, Kit-positive cells were located near to SCF-positive cells, and SCF/Kit double-positive tumour cells were found. Ki67-positive tumour cells were not found near to SCF-positive cells. These results suggest that SCF autocrine/paracrine mechanisms are involved in the expansion of cutaneous MCTs, but not in tumour proliferation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Neoplasms
/
Mastocytosis
/
Cat Diseases
/
Stem Cell Factor
/
Mastocytoma, Skin
Limits:
Animals
Language:
En
Journal:
J Comp Pathol
Year:
2018
Document type:
Article
Affiliation country: