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Targeting Cytochrome P450 (CYP) 1B1 Enzyme with Four Series of A-Ring Substituted Estrane Derivatives: Design, Synthesis, Inhibitory Activity, and Selectivity.
Dutour, Raphaël; Roy, Jenny; Cortés-Benítez, Francisco; Maltais, René; Poirier, Donald.
Affiliation
  • Dutour R; Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit , CHU de Québec-Research Center , 2705 Laurier Boulevard , Québec , Québec G1V 4G2 , Canada.
  • Roy J; Department of Molecular Medicine, Faculty of Medicine , Université Laval , Québec , Québec G1V 4G2 , Canada.
  • Cortés-Benítez F; Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit , CHU de Québec-Research Center , 2705 Laurier Boulevard , Québec , Québec G1V 4G2 , Canada.
  • Maltais R; Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit , CHU de Québec-Research Center , 2705 Laurier Boulevard , Québec , Québec G1V 4G2 , Canada.
  • Poirier D; Department of Pharmacy, Faculty of Chemistry , National Autonomous University of Mexico , Mexico City , 04510 , Mexico.
J Med Chem ; 61(20): 9229-9245, 2018 10 25.
Article in En | MEDLINE | ID: mdl-30216063
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Estranes / Cytochrome P-450 CYP1B1 / Cytochrome P-450 Enzyme Inhibitors Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Estranes / Cytochrome P-450 CYP1B1 / Cytochrome P-450 Enzyme Inhibitors Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: Country of publication: