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Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKε for the treatment of obesity.
Beyett, Tyler S; Gan, Xinmin; Reilly, Shannon M; Gomez, Andrew V; Chang, Louise; Tesmer, John J G; Saltiel, Alan R; Showalter, Hollis D.
Affiliation
  • Beyett TS; Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109, United States; Life Sciences Institute, Departments of Pharmacology and Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, United States.
  • Gan X; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, United States; Vahlteich Medicinal Chemistry Core, University of Michigan, Ann Arbor, MI 48109, United States.
  • Reilly SM; Departments of Medicine and Pharmacology, Institute for Diabetes and Metabolic Health, University of California, San Diego, La Jolla, CA 92093-0912, United States.
  • Gomez AV; Departments of Medicine and Pharmacology, Institute for Diabetes and Metabolic Health, University of California, San Diego, La Jolla, CA 92093-0912, United States.
  • Chang L; Life Sciences Institute, Departments of Pharmacology and Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, United States.
  • Tesmer JJG; Life Sciences Institute, Departments of Pharmacology and Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, United States.
  • Saltiel AR; Departments of Medicine and Pharmacology, Institute for Diabetes and Metabolic Health, University of California, San Diego, La Jolla, CA 92093-0912, United States.
  • Showalter HD; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, United States; Vahlteich Medicinal Chemistry Core, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: showalh@umich.edu.
Bioorg Med Chem ; 26(20): 5443-5461, 2018 11 01.
Article in En | MEDLINE | ID: mdl-30270002
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Protein Serine-Threonine Kinases / Protein Kinase Inhibitors / I-kappa B Kinase / Obesity Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Protein Serine-Threonine Kinases / Protein Kinase Inhibitors / I-kappa B Kinase / Obesity Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Document type: Article Affiliation country: