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Chemical synthesis of C3-oxiranyl/oxiranylmethyl-estrane derivatives targeted by molecular modeling and tested as potential inhibitors of 17ß-hydroxysteroid dehydrogenase type 1.
Lespérance, Maxime; Barbeau, Xavier; Roy, Jenny; Maltais, René; Lagüe, Patrick; Poirier, Donald.
Affiliation
  • Lespérance M; Laboratory of Medicinal Chemistry, Oncology and Nephrology Unit, CHU de Québec - Research Center (CHUL T4), Québec, QC, Canada; Department of Molecular Medicine, Faculty of Medicine, Université Laval, Québec, QC, Canada.
  • Barbeau X; Department of Chemistry, Faculty of Science and Engineering, Université Laval, Québec, QC, Canada; Institut de Biologie Intégrative et des Systèmes (IBIS), and Centre de Recherche sur la Fonction, la Structure et l'Ingénierie des Protéines (PROTEO), Université Laval, Québec, QC, Canada.
  • Roy J; Laboratory of Medicinal Chemistry, Oncology and Nephrology Unit, CHU de Québec - Research Center (CHUL T4), Québec, QC, Canada.
  • Maltais R; Laboratory of Medicinal Chemistry, Oncology and Nephrology Unit, CHU de Québec - Research Center (CHUL T4), Québec, QC, Canada.
  • Lagüe P; Department of Biochemistry, Microbiology and Bioinformatic, Faculty of Science and Engineering, Université Laval, Québec, QC, Canada; Institut de Biologie Intégrative et des Systèmes (IBIS), and Centre de Recherche sur la Fonction, la Structure et l'Ingénierie des Protéines (PROTEO), Université Lava
  • Poirier D; Laboratory of Medicinal Chemistry, Oncology and Nephrology Unit, CHU de Québec - Research Center (CHUL T4), Québec, QC, Canada; Department of Molecular Medicine, Faculty of Medicine, Université Laval, Québec, QC, Canada. Electronic address: donald.poirier@crchul.ulaval.ca.
Steroids ; 140: 104-113, 2018 12.
Article in En | MEDLINE | ID: mdl-30273695
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enzyme Inhibitors / Estranes / Molecular Docking Simulation / 17-Hydroxysteroid Dehydrogenases Limits: Humans Language: En Journal: Steroids Year: 2018 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enzyme Inhibitors / Estranes / Molecular Docking Simulation / 17-Hydroxysteroid Dehydrogenases Limits: Humans Language: En Journal: Steroids Year: 2018 Document type: Article Affiliation country: Country of publication: