Genomic Characterization of Carbapenemase-Producing Klebsiella pneumoniae with Chromosomally Carried blaNDM-1.
Antimicrob Agents Chemother
; 62(12)2018 12.
Article
in En
| MEDLINE
| ID: mdl-30323033
ABSTRACT
We report here Klebsiella pneumoniae strains carrying chromosomal blaNDM-1 in Thailand. The genomes of these two isolates include a 160-kbp insertion containing blaNDM-1, which is almost identical to that in the IncHI1B-like plasmid. Further analysis indicated that IS5-mediated intermolecular transposition and Tn3 transposase-mediated homologous recombination resulted in the integration of blaNDM-1 into the chromosome from an IncHI1B-like plasmid. The spread of this type of carbapenem-resistant Enterobacteriaceae may threaten public health and warrants further monitoring.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plasmids
/
Beta-Lactamases
/
Mutagenesis, Insertional
/
Chromosomes, Bacterial
/
Genome, Bacterial
/
Klebsiella pneumoniae
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
2018
Document type:
Article
Affiliation country: