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Genomic Characterization of Carbapenemase-Producing Klebsiella pneumoniae with Chromosomally Carried blaNDM-1.
Sakamoto, Noriko; Akeda, Yukihiro; Sugawara, Yo; Takeuchi, Dan; Motooka, Daisuke; Yamamoto, Norihisa; Laolerd, Warawut; Santanirand, Pitak; Hamada, Shigeyuki.
Affiliation
  • Sakamoto N; Japan-Thailand Research Collaboration Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
  • Akeda Y; Japan-Thailand Research Collaboration Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan akeda@biken.osaka-u.ac.jp.
  • Sugawara Y; Division of Infection Control and Prevention, Osaka University Hospital, Osaka University, Osaka, Japan.
  • Takeuchi D; Department of Infection Control and Prevention, Graduate School of Medicine, Osaka University, Osaka, Japan.
  • Motooka D; Japan-Thailand Research Collaboration Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
  • Yamamoto N; Japan-Thailand Research Collaboration Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
  • Laolerd W; Department of Infection Metagenomics, Genome Information Center, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
  • Santanirand P; Japan-Thailand Research Collaboration Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
  • Hamada S; Division of Infection Control and Prevention, Osaka University Hospital, Osaka University, Osaka, Japan.
Antimicrob Agents Chemother ; 62(12)2018 12.
Article in En | MEDLINE | ID: mdl-30323033
ABSTRACT
We report here Klebsiella pneumoniae strains carrying chromosomal blaNDM-1 in Thailand. The genomes of these two isolates include a 160-kbp insertion containing blaNDM-1, which is almost identical to that in the IncHI1B-like plasmid. Further analysis indicated that IS5-mediated intermolecular transposition and Tn3 transposase-mediated homologous recombination resulted in the integration of blaNDM-1 into the chromosome from an IncHI1B-like plasmid. The spread of this type of carbapenem-resistant Enterobacteriaceae may threaten public health and warrants further monitoring.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmids / Beta-Lactamases / Mutagenesis, Insertional / Chromosomes, Bacterial / Genome, Bacterial / Klebsiella pneumoniae Limits: Humans Country/Region as subject: Asia Language: En Journal: Antimicrob Agents Chemother Year: 2018 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmids / Beta-Lactamases / Mutagenesis, Insertional / Chromosomes, Bacterial / Genome, Bacterial / Klebsiella pneumoniae Limits: Humans Country/Region as subject: Asia Language: En Journal: Antimicrob Agents Chemother Year: 2018 Document type: Article Affiliation country: