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BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes.
Sasanuma, Hiroyuki; Tsuda, Masataka; Morimoto, Suguru; Saha, Liton Kumar; Rahman, Md Maminur; Kiyooka, Yusuke; Fujiike, Haruna; Cherniack, Andrew D; Itou, Junji; Callen Moreu, Elsa; Toi, Masakazu; Nakada, Shinichiro; Tanaka, Hisashi; Tsutsui, Ken; Yamada, Shintaro; Nussenzweig, Andre; Takeda, Shunichi.
Affiliation
  • Sasanuma H; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan; hiroysasa@rg.med.kyoto-u.ac.jp stakeda@rg.med.kyoto-u.ac.jp.
  • Tsuda M; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan.
  • Morimoto S; Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 739-8526 Higashi-Hiroshima, Japan.
  • Saha LK; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan.
  • Rahman MM; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan.
  • Kiyooka Y; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan.
  • Fujiike H; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan.
  • Cherniack AD; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan.
  • Itou J; The Eli and Edythe L. Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142.
  • Callen Moreu E; Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 606-8507 Kyoto, Japan.
  • Toi M; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD 20892.
  • Nakada S; Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 606-8507 Kyoto, Japan.
  • Tanaka H; Department of Bioregulation and Cellular Response, Graduate School of Medicine, Osaka University, Suita, 565-0871 Osaka, Japan.
  • Tsutsui K; Department of Surgery, Cedars-Sinai Medical Center, West Hollywood, CA 90048.
  • Yamada S; Department of Neurogenomics, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, 700-8558 Okayama, Japan.
  • Nussenzweig A; Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan.
  • Takeda S; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD 20892.
Proc Natl Acad Sci U S A ; 115(45): E10642-E10651, 2018 11 06.
Article in En | MEDLINE | ID: mdl-30352856
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / DNA Topoisomerases, Type II / BRCA1 Protein / Genomic Instability / Carcinogenesis Limits: Animals / Female / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / DNA Topoisomerases, Type II / BRCA1 Protein / Genomic Instability / Carcinogenesis Limits: Animals / Female / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Document type: Article