A facile synthesis of ursodeoxycholic acid and obeticholic acid from cholic acid.
Steroids
; 140: 173-178, 2018 12.
Article
in En
| MEDLINE
| ID: mdl-30389306
ABSTRACT
A novel synthetic route of producing ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) was developed through multiple reactions from cheap and readily-available cholic acid. The reaction conditions of the key elimination reaction of mesylate ester group were also investigated and optimized, including solvent, base and reaction temperature. In the straightforward synthetic route for preparation of UDCA and OCA, most of the reaction steps have high conversions with average yields of 94% and 92%, and overall yield up to 65% (7 steps) and 36% (11 steps) from cholic acid, respectively. This promising route offers economical and efficient strategies for potential large-scale production of UDCA and OCA.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ursodeoxycholic Acid
/
Chenodeoxycholic Acid
/
Cholic Acid
Language:
En
Journal:
Steroids
Year:
2018
Document type:
Article
Affiliation country: