Effects of glucose on insulin release and 86Rb permeability in cultured neonatal and adult rat islets.
FEBS Lett
; 236(2): 375-9, 1988 Aug 29.
Article
in En
| MEDLINE
| ID: mdl-3044829
ABSTRACT
Glucose-induced insulin release and modifications in 86Rb outflow were studied in cultured neonatal and adult rat islets. The dose-response curve for neonatal islets was steeper than for adult islets and the maximal response was clearly shifted towards lower glucose concentrations. In neonatal islets, glucose-induced insulin release was inhibited by the Ca2+-channel blocker, nifedipine. In the absence of glucose, the 86Rb outflow from neonatal islets was lower than from adult islets. Also, the glucose-induced reduction in 86Rb outflow was less pronounced in neonatal islets. Altered K+ permeability in the B-cell membrane could explain the change in glucose sensitivity of neonatal islets.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Membrane Permeability
/
Islets of Langerhans
/
Glucose
/
Insulin
Limits:
Animals
Language:
En
Journal:
FEBS Lett
Year:
1988
Document type:
Article