Congenital tuberculosis after in vitro fertilization: suggestion for tuberculosis tests in infertile women in developing countries.
J Int Med Res
; 46(12): 5316-5321, 2018 Dec.
Article
in En
| MEDLINE
| ID: mdl-30453806
ABSTRACT
Congenital tuberculosis (CTB) after in vitro fertilization (IVF) is a major new problem in developing countries. Only 16 cases of CTB after IVF have been reported, and no tuberculosis (TB) tests were performed before IVF in these cases. However, on the basis of data in the literature and from the World Health Organization, the incidence of CTB has been substantially underestimated. We describe two cases of CTB after IVF in detail in our center and provide new insight into the important issue of controlling TB vertical transmission in developing countries. Performing an early diagnosis of CTB, mostly based on evidence of maternal infection and a high index of clinical suspicion, is a challenge. However, most mothers have no symptoms of TB infection during prepartum, and infertility may be the only symptom. Infertility caused by genital TB is common in countries with a high TB burden, and IVF is considered to be an effective treatment to improve their fertility. Therefore, this may lead to more CTB cases without thorough TB tests before IVF. We suggest that thorough TB tests should be conducted in infertile women before IVF to prevent CTB.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tuberculosis
/
Tuberculosis, Female Genital
/
Tuberculin Test
/
Fertilization in Vitro
/
Infectious Disease Transmission, Vertical
/
Diseases in Twins
/
Infertility, Female
Type of study:
Etiology_studies
/
Screening_studies
Limits:
Female
/
Humans
/
Male
/
Newborn
Language:
En
Journal:
J Int Med Res
Year:
2018
Document type:
Article
Affiliation country: