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Dual carrier-cargo hydrophobization and charge ratio optimization improve the systemic circulation and safety of zwitterionic nano-polyplexes.
Jackson, Meredith A; Bedingfield, Sean K; Yu, Fang; Stokan, Mitchell E; Miles, Rachel E; Curvino, Elizabeth J; Hoogenboezem, Ella N; Bonami, Rachel H; Patel, Shrusti S; Kendall, Peggy L; Giorgio, Todd D; Duvall, Craig L.
Affiliation
  • Jackson MA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
  • Bedingfield SK; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
  • Yu F; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
  • Stokan ME; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
  • Miles RE; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
  • Curvino EJ; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
  • Hoogenboezem EN; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
  • Bonami RH; Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Patel SS; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
  • Kendall PL; Department of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Giorgio TD; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
  • Duvall CL; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA. Electronic address: craig.duvall@vanderbilt.edu.
Biomaterials ; 192: 245-259, 2019 02.
Article in En | MEDLINE | ID: mdl-30458360

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymers / RNA, Small Interfering / Nanostructures Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Biomaterials Year: 2019 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymers / RNA, Small Interfering / Nanostructures Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Biomaterials Year: 2019 Document type: Article Affiliation country: Country of publication: