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Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states.
Lake, Eric W; Muretta, Joseph M; Thompson, Andrew R; Rasmussen, Damien M; Majumdar, Abir; Faber, Erik B; Ruff, Emily F; Thomas, David D; Levinson, Nicholas M.
Affiliation
  • Lake EW; Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455.
  • Muretta JM; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455.
  • Thompson AR; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455.
  • Rasmussen DM; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455.
  • Majumdar A; Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455.
  • Faber EB; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455.
  • Ruff EF; Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455.
  • Thomas DD; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455.
  • Levinson NM; Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455; nml@umn.edu.
Proc Natl Acad Sci U S A ; 115(51): E11894-E11903, 2018 12 18.
Article in En | MEDLINE | ID: mdl-30518564
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Conformation / Protein Kinase Inhibitors / Protein Interaction Domains and Motifs / Aurora Kinase A Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Conformation / Protein Kinase Inhibitors / Protein Interaction Domains and Motifs / Aurora Kinase A Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Document type: Article Country of publication: