Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients.
J Immunother Cancer
; 6(1): 139, 2018 12 04.
Article
in En
| MEDLINE
| ID: mdl-30526667
ABSTRACT
A high density of tumor-infiltrating CD8+ T cells and CD20+ B cells correlates with prolonged survival in patients with a wide variety of human cancers, including high-grade serous ovarian carcinoma (HGSC). However, the potential impact of mature dendritic cells (DCs) in shaping the immune contexture of HGSC, their role in the establishment of T cell-dependent antitumor immunity, and their potential prognostic value for HGSC patients remain unclear. We harnessed immunohistochemical tests and biomolecular analyses to demonstrate that a high density of tumor-infiltrating DC-LAMP+ DCs is robustly associated with an immune contexture characterized by TH1 polarization and cytotoxic activity. We showed that both mature DCs and CD20+ B cells play a critical role in the generation of a clinically-favorable cytotoxic immune response in HGSC microenvironment. In line with this notion, robust tumor infiltration by both DC-LAMP+ DCs and CD20+ B cells was associated with most favorable overall survival in two independent cohorts of chemotherapy-naïve HGSC patients. Our findings suggest that the presence of mature, DC-LAMP+ DCs in the tumor microenvironment may represent a novel, powerful prognostic biomarker for HGSC patients that reflects the activation of clinically-relevant anticancer immunity.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovarian Neoplasms
/
Dendritic Cells
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Carcinoma
/
Tumor Microenvironment
Type of study:
Prognostic_studies
Limits:
Adult
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Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
J Immunother Cancer
Year:
2018
Document type:
Article
Affiliation country: