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SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.
Tzelepis, Konstantinos; De Braekeleer, Etienne; Aspris, Demetrios; Barbieri, Isaia; Vijayabaskar, M S; Liu, Wen-Hsin; Gozdecka, Malgorzata; Metzakopian, Emmanouil; Toop, Hamish D; Dudek, Monika; Robson, Samuel C; Hermida-Prado, Francisco; Yang, Yu Hsuen; Babaei-Jadidi, Roya; Garyfallos, Dimitrios A; Ponstingl, Hannes; Dias, Joao M L; Gallipoli, Paolo; Seiler, Michael; Buonamici, Silvia; Vick, Binje; Bannister, Andrew J; Rad, Roland; Prinjha, Rab K; Marioni, John C; Huntly, Brian; Batson, Jennifer; Morris, Jonathan C; Pina, Cristina; Bradley, Allan; Jeremias, Irmela; Bates, David O; Yusa, Kosuke; Kouzarides, Tony; Vassiliou, George S.
Affiliation
  • Tzelepis K; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK. kt404@cam.ac.uk.
  • De Braekeleer E; Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QN, UK. kt404@cam.ac.uk.
  • Aspris D; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Barbieri I; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Vijayabaskar MS; Karaiskakio Foundation, Nicosia, Cyprus.
  • Liu WH; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Addenbrookes Hospital, CB2 0QQ, Cambridge, UK.
  • Gozdecka M; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Metzakopian E; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), 81377, Munich, Germany.
  • Toop HD; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Dudek M; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0XY, UK.
  • Robson SC; UK Dementia Research Institute, University of Cambridge, Hills Rd, Cambridge, CB2 0AH, UK.
  • Hermida-Prado F; School of Chemistry, University of New South Wales, Sydney, Australia.
  • Yang YH; Exonate Ltd, Milton Science Park, Cambridge, UK.
  • Babaei-Jadidi R; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Garyfallos DA; School of Pharmacy and Biomedical Science, University of Portsmouth, White Swan Road, Portsmouth, PO1 2DT, UK.
  • Ponstingl H; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Dias JML; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Gallipoli P; School of Chemistry, University of New South Wales, Sydney, Australia.
  • Seiler M; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Buonamici S; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
  • Vick B; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  • Bannister AJ; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
  • Rad R; Cancer Molecular Diagnosis Laboratory, National Institute for Health Research, Biomedical Research Centre, University of Cambridge, Cambridge, UK.
  • Prinjha RK; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0XY, UK.
  • Marioni JC; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK.
  • Huntly B; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, CB2 0QQ, UK.
  • Batson J; H3 Biomedicine Inc., Cambridge, MA, USA.
  • Morris JC; H3 Biomedicine Inc., Cambridge, MA, USA.
  • Pina C; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), 81377, Munich, Germany.
  • Bradley A; Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QN, UK.
  • Jeremias I; Institute of Molecular Oncology and Functional Genomics, Department of Medicine II and TranslaTUM Cancer Center, Technical University of Munich, Germany.
  • Bates DO; German Cancer Research Center (DKFZ), Heidelberg, & German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Yusa K; Epigenetics DPU, Immunoinflammation and Oncology TA Unit, GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK.
  • Kouzarides T; Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK.
  • Vassiliou GS; European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.
Nat Commun ; 9(1): 5378, 2018 12 19.
Article in En | MEDLINE | ID: mdl-30568163
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Nuclear Proteins / Leukemia, Myeloid, Acute / Protein Serine-Threonine Kinases Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2018 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Nuclear Proteins / Leukemia, Myeloid, Acute / Protein Serine-Threonine Kinases Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2018 Document type: Article Affiliation country: