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Indole-2-Carboxamides Are Active against Mycobacterium abscessus in a Mouse Model of Acute Infection.
Pandya, Amit N; Prathipati, Pavan K; Hegde, Pooja; Li, Wei; Graham, Kyle F; Mandal, Subhra; Drescher, Kristen M; Destache, Christopher J; Ordway, Diane; Jackson, Mary; North, E Jeffrey.
Affiliation
  • Pandya AN; Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University, Omaha, Nebraska, USA.
  • Prathipati PK; Department of Pharmacy Practice, School of Pharmacy and Health Professions, Creighton University, Omaha, Nebraska, USA.
  • Hegde P; Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University, Omaha, Nebraska, USA.
  • Li W; Department of Pharmacy Practice, School of Pharmacy and Health Professions, Creighton University, Omaha, Nebraska, USA.
  • Graham KF; Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University, Omaha, Nebraska, USA.
  • Mandal S; Department of Pharmacy Practice, School of Pharmacy and Health Professions, Creighton University, Omaha, Nebraska, USA.
  • Drescher KM; Department of Medical Microbiology & Immunology, School of Medicine, Creighton University, Omaha, Nebraska, USA.
  • Destache CJ; Department of Pharmacy Practice, School of Pharmacy and Health Professions, Creighton University, Omaha, Nebraska, USA.
  • Ordway D; Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado, USA.
  • Jackson M; Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado, USA.
  • North EJ; Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University, Omaha, Nebraska, USA jeffreynorth@creighton.edu.
Antimicrob Agents Chemother ; 63(3)2019 03.
Article in En | MEDLINE | ID: mdl-30602519
ABSTRACT
Nontuberculous mycobacteria (NTM) pathogens particularly infect patients with structural lung disorders. We previously reported novel indole-2-carboxamides (ICs) that are active against a wide panel of NTM pathogens. This study discloses in vivo data for two lead molecules (compounds 5 and 25) that were advanced for efficacy studies in Mycobacterium abscessus-infected mouse models. Oral administration of the lead molecules showed a statistically significant reduction in the bacterial loads in lung and spleen of M. abscessus-infected mice.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mycobacterium abscessus / Indoles / Anti-Bacterial Agents / Mycobacterium Infections, Nontuberculous Limits: Animals Language: En Journal: Antimicrob Agents Chemother Year: 2019 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mycobacterium abscessus / Indoles / Anti-Bacterial Agents / Mycobacterium Infections, Nontuberculous Limits: Animals Language: En Journal: Antimicrob Agents Chemother Year: 2019 Document type: Article Affiliation country: